Please use this identifier to cite or link to this item: 10.1515/prolas-2016-0028
Title: Effect of Human Herpesviruses 6 and 7 Infection on the Clinical Course of Rheumatoid Arthritis
Authors: Kadiša, Anda
Nora-Krūkle, Zaiga
Kozireva, Svetlana
Svirskis, Simons
Studers, Peteris
Groma, Valerija
Lejnieks, Aivars
Murovska, Modra
Department of Internal Diseases
Institute of Microbiology and Virology
Joint Laboratory of Traumatology and Orthopaedics
Institute of Anatomy and Anthropology
Keywords: HHV-6;HHV-7;rheumatoid arthritis;viral reactivation;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;General
Issue Date: 1-Aug-2016
Citation: Kadiša , A , Nora-Krūkle , Z , Kozireva , S , Svirskis , S , Studers , P , Groma , V , Lejnieks , A & Murovska , M 2016 , ' Effect of Human Herpesviruses 6 and 7 Infection on the Clinical Course of Rheumatoid Arthritis ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 70 , no. 4 , pp. 165-174 . https://doi.org/10.1515/prolas-2016-0028
Abstract: Rheumatoid arthritis (RA) is a chronic systemic autoimmune inflammatory disease affecting joints and causing symmetrical chronic progressive aseptic synovitis and erosive-destructive changes. Viruses and viral infections are considered to be the main risk factors for autoimmune disease development (especially for individuals with genetic predisposition). The goal of this study was to evaluate the frequency of HHV-6 and HHV-7 persistent infection and its activity phase in RA and osteoarthritis (OA) patients, and healthy persons. We examined also the influence of HHV-6 and-7 infections on RA activity, aggressiveness, radiographical stage, and frequency of complications as well as the presence of HHV-6 infection markers in synovial fluid and synovial tissues of RA joints of affected patients. Despite the lack of significant correlation between frequency of persistent single HHV-6, single HHV-7, and concurrent HHV-6 and HHV-7 infection and RA clinical course, we found that both active and latent HHV-6 and/or HHV-7 infection increased RA activity and progression in several clinical and laboratory parameters. Regarding the severity of the course of RA, we observed also a high prevalence of RA complications in the patient group with active single HHV-6 infection and also a more severe radiographical stage in RA patients with active concurrent HHV-6 and HHV-7 infection. Moreover, viral infection markers were found in synovial fluid and synovial tissues of affected joints of RA patients. This suggests that HHV-6 and/or HHV-7 infection has effect on the disease clinical course, but virus reactivation may be a consequence of immunosuppressive treatment.
Description: Publisher Copyright: © 2016 by Anda Kadiša. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
DOI: 10.1515/prolas-2016-0028
ISSN: 1407-009X
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

Files in This Item:


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.