Please use this identifier to cite or link to this item:
10.3390/medicina55090563
Title: | Polymorphism rs2066865 in the Fibrinogen Gamma chain (FGG) gene increases plasma fibrinogen concentration and is associated with an increased microvascular thrombosis rate |
Authors: | Drizlionoka, Karina Zariņš, Jānis Ozoliņa, Agnese Ņikitina-Zaķe, Liene Mamaja, Biruta Department of Anaesthesiology and Intensive Care |
Keywords: | Fibrinogen;Fibrinogen gamma chain gene;Free flap failure;Free tissue transfer;Microvascular flap thrombosis;Polymorphism;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine |
Issue Date: | Sep-2019 |
Citation: | Drizlionoka , K , Zariņš , J , Ozoliņa , A , Ņikitina-Zaķe , L & Mamaja , B 2019 , ' Polymorphism rs2066865 in the Fibrinogen Gamma chain (FGG) gene increases plasma fibrinogen concentration and is associated with an increased microvascular thrombosis rate ' , Medicina (Lithuania) , vol. 55 , no. 9 , 563 . https://doi.org/10.3390/medicina55090563 |
Abstract: | Background and Objective: Thrombosis due to inherited hypercoagulability is an issue that has been raised in microvascular flap surgery previously. We analyzed the association of a single nucleotide polymorphism (SNP) in rs2066865 in the fibrinogen gamma chain (FGG) gene, alteration in plasma fibrinogen concentration, and presence of microvascular flap thrombosis. Materials and Methods: A total of 104 adult patients with microvascular flap surgery were subjected to an analysis of the presence of SNP rs2066865 in the FGG gene. Alterations in plasma fibrinogen concentration according to genotype were determined as a primary outcome, and flap thrombosis was defined as a secondary outcome. Results: Flap thrombosis was detected in 11.5% of patients (n = 12). Successful revision of anastomosis was performed in four patients, resulting in a microvascular flap survival rate of 92.3%. We observed an increase in plasma fibrinogen concentration in genotype G/A and A/A carriers (G/G, 3.9 (IQR 4.76-3.04); G/A, 4.28 (IQR 5.38-3.18); A/A, 6.87 (IQR 8.25-5.49) (A/A vs. G/A, p = 0.003 and A/A vs. G/G, p = 0.001). Within group differences in microvascular flap thrombosis incidence rates were observed—G/G 6/79 (7.59%); G/A 5/22 (22.7%); A/A 1/3 (33.3%) (OR 0.30 95%; CI 0.044 to 0.57), p = 0.016; RR 3.2—when G/G versus G/A and A/A were analyzed respectively. Conclusions: A/A and G/A genotype carriers of a single nucleotide polymorphism in rs2066865 in the fibrinogen gamma chain gene had a higher plasma fibrinogen concentration, and this might be associated with an increased microvascular flap thrombosis incidence rate. Determined polymorphism could be considered as a genetic marker associated with microvascular flap thrombosis development. To confirm the results of this study, the data should be replicated in a greater sample size. |
Description: | Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
DOI: | 10.3390/medicina55090563 |
ISSN: | 1010-660X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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