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Title: Human bocavirus infection markers in peripheral blood and stool samples of children with acute gastroenteritis
Authors: Nora-Krukle, Zaiga
Vilmane, Anda
Xu, Man
Rasa, Santa
Ziemele, Inga
Silina, Elina
Söderlund-Venermo, Maria
Gardovska, Dace
Murovska, Modra
Institute of Microbiology and Virology
Department of Paediatrics
Keywords: Acute gastroenteritis;Children;Human bocavirus;Infectious Diseases;Virology;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database
Issue Date: 15-Nov-2018
Citation: Nora-Krukle , Z , Vilmane , A , Xu , M , Rasa , S , Ziemele , I , Silina , E , Söderlund-Venermo , M , Gardovska , D & Murovska , M 2018 , ' Human bocavirus infection markers in peripheral blood and stool samples of children with acute gastroenteritis ' , Viruses , vol. 10 , no. 11 , 639 .
Abstract: Human bocaviruses (HBoVs) 1–4 belong to the Parvoviridae family, and they infect the respiratory or gastrointestinal tracts in children. We investigated the prevalence of HBoV1–4 DNAs in the blood and stool samples, and of HBoV1–4 IgG and IgM in the plasma samples, of children presenting with acute gastroenteritis (AGE). In addition, we identified HBoV co-infections with the five most frequent gastrointestinal pathogens. A total of 83 paired blood and stool samples were collected from children aged five years or less. Infection markers of HBoV1, 2, or 3 (viral DNA in blood and/or stool and/or antibodies) were detected in 61 out of 83 (73.5%) patients. HBoV1, 2, or 3 DNA as a monoinfection was revealed in 18.1%, 2.4%, and 1.2%, respectively, and 21.7% in totalIn 56.1% of the HBoV DNA-positive patients, the presence in stool of another virus—most frequently norovirus or rotavirus—was observed. In conclusion, this study, for the first time, illustrates the prevalence and genetic diversity of HBoVs in Latvian children with gastroenteritis, and shows a widespread distribution of these viruses in the community. HBoV1 and 2 are commonly found as single infectious agents in children with AGE, suggesting that the viruses can be as pathogenic by themselves as other enteric agents are.
Description: Publisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
ISSN: 1999-4915
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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