Please use this identifier to cite or link to this item:
10.3390/genes10020083
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Salmina, Kristine | - |
dc.contributor.author | Huna, Anda | - |
dc.contributor.author | Kalejs, Martins | - |
dc.contributor.author | Pjanova, Dace | - |
dc.contributor.author | Scherthan, Harry | - |
dc.contributor.author | Cragg, Mark S. | - |
dc.contributor.author | Erenpreisa, Jekaterina | - |
dc.date.accessioned | 2021-04-16T14:05:01Z | - |
dc.date.available | 2021-04-16T14:05:01Z | - |
dc.date.issued | 2019-01-01 | - |
dc.identifier.citation | Salmina , K , Huna , A , Kalejs , M , Pjanova , D , Scherthan , H , Cragg , M S & Erenpreisa , J 2019 , ' The cancer aneuploidy paradox : In the light of evolution ' , Genes , vol. 10 , no. 2 , 83 . https://doi.org/10.3390/genes10020083 | - |
dc.identifier.issn | 2073-4425 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3830 | - |
dc.description | Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | Aneuploidy should compromise cellular proliferation but paradoxically favours tumour progression and poor prognosis. Here, we consider this paradox in terms of our most recent observations of chemo/radio-resistant cells undergoing reversible polyploidy. The latter perform the segregation of two parental groups of end-to-end linked dyads by pseudo-mitosis creating tetraploid cells through a dysfunctional spindle. This is followed by autokaryogamy and a homologous pairing preceding a bi-looped endo-prophase. The associated RAD51 and DMC1/γ- H2AX double-strand break repair foci are tandemly situated on the AURKB/REC8/kinetochore doublets along replicated chromosome loops, indicative of recombination events. MOS-associated REC8-positive peri-nucleolar centromere cluster organises a monopolar spindle. The process is completed by reduction divisions (bi-polar or by radial cytotomy including pedogamic exchanges) and by the release of secondary cells and/or the formation of an embryoid. Together this process preserves genomic integrity and chromosome pairing, while tolerating aneuploidy by by-passing the mitotic spindle checkpoint. Concurrently, it reduces the chromosome number and facilitates recombination that decreases the mutation load of aneuploidy and lethality in the chemo-resistant tumour cells. This cancer life-cycle has parallels both within the cycling polyploidy of the asexual life cycles of ancient unicellular protists and cleavage embryos of early multicellulars, supporting the atavistic theory of cancer. | en |
dc.format.extent | 22 | - |
dc.format.extent | 4681542 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Genes | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Aneuploidy | - |
dc.subject | Autokaryogamy | - |
dc.subject | Cancer | - |
dc.subject | Chromothripsis | - |
dc.subject | Cleavage embryo | - |
dc.subject | Disabled spindle | - |
dc.subject | Meio-mitosis | - |
dc.subject | Recombination on kinetochores | - |
dc.subject | Reduction | - |
dc.subject | Somatic pairing | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Genetics | - |
dc.subject | Genetics(clinical) | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | The cancer aneuploidy paradox : In the light of evolution | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/genes10020083 | - |
dc.contributor.institution | Scientific Laboratory of Biomechanics | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85061937762&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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The_Cancer_Aneuploidy_Paradox.pdf | 4.57 MB | Adobe PDF | View/Open |
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