Please use this identifier to cite or link to this item:
10.1186/s13256-019-2222-5
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DC Field | Value | Language |
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dc.contributor.author | Ziemele, Inga | - |
dc.contributor.author | Xu, Man | - |
dc.contributor.author | Vilmane, Anda | - |
dc.contributor.author | Rasa-Dzelzkaleja, Santa | - |
dc.contributor.author | Hedman, Lea | - |
dc.contributor.author | Hedman, Klaus | - |
dc.contributor.author | Söderlund-Venermo, Maria | - |
dc.contributor.author | Nora-Krukle, Zaiga | - |
dc.contributor.author | Murovska, Modra | - |
dc.contributor.author | Gardovska, Dace | - |
dc.date.accessioned | 2021-04-13T11:30:01Z | - |
dc.date.available | 2021-04-13T11:30:01Z | - |
dc.date.issued | 2019-09-14 | - |
dc.identifier.citation | Ziemele , I , Xu , M , Vilmane , A , Rasa-Dzelzkaleja , S , Hedman , L , Hedman , K , Söderlund-Venermo , M , Nora-Krukle , Z , Murovska , M & Gardovska , D 2019 , ' Acute human bocavirus 1 infection in child with life-threatening bilateral bronchiolitis and right-sided pneumonia : a case report ' , Journal of Medical Case Reports , vol. 13 , no. 1 , pp. 290 . https://doi.org/10.1186/s13256-019-2222-5 | - |
dc.identifier.issn | 1752-1947 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3783 | - |
dc.description | Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine | - |
dc.description.abstract | BACKGROUND: Human bocavirus 1 is a commonly detected human parvovirus. Many studies have shown human bocavirus 1 as a pathogen in association with acute respiratory tract infections in children. However, because human bocavirus 1 persists in the upper airways for extensive time periods after acute infection, the definition and diagnostics of acute human bocavirus 1 infection is challenging. Until now, detection of human bocavirus 1 exclusively, high viral load in respiratory samples, and viremia have been associated with a clinical picture of acute respiratory illness. There are no studies showing detection of human bocavirus 1 messenger ribonucleic acid in the peripheral blood mononuclear cells as a diagnostic marker for acute lower respiratory tract infection. CASE PRESENTATION: We report the case of a 17-month-old Latvian boy who presented in intensive care unit with acute bilateral bronchiolitis, with a history of rhinorrhea and cough for 6 days and fever for the last 2 days prior to admission, followed by severe respiratory distress and tracheal intubation. Human bocavirus 1 was the only respiratory virus detected by a qualitative multiplex polymerase chain reaction panel. For the diagnosis of acute human bocavirus 1 infection, both molecular and serological approaches were used. Human bocavirus 1 deoxyribonucleic acid (DNA) was detected simultaneously in nasopharyngeal aspirate, stool, and blood, as well as in the corresponding cell-free blood plasma by qualitative and quantitative polymerase chain reaction, revealing high DNA-copy numbers in nasopharyngeal aspirate and stool. Despite a low-load viremia, human bocavirus 1 messenger ribonucleic acid was found in the peripheral blood mononuclear cells. For detection of human bocavirus 1-specific antibodies, non-competitive immunoglobulin M and competitive immunoglobulin G enzyme immunoassays were used. The plasma was positive for both human bocavirus 1-specific immunoglobulin M and immunoglobulin G antibodies. CONCLUSIONS: The presence of human bocavirus 1 genomic DNA in blood plasma and human bocavirus 1 messenger ribonucleic acid in peripheral blood mononuclear cells together with human bocavirus 1-specific immunoglobulin M are markers of acute human bocavirus 1 infection that may cause life-threatening acute bronchiolitis. | en |
dc.format.extent | 1 | - |
dc.format.extent | 721372 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Journal of Medical Case Reports | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Acute bronchiolitis | - |
dc.subject | Children | - |
dc.subject | Human bocavirus 1 | - |
dc.subject | Lower respiratory tract infection | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Acute human bocavirus 1 infection in child with life-threatening bilateral bronchiolitis and right-sided pneumonia : a case report | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1186/s13256-019-2222-5 | - |
dc.contributor.institution | Department of Paediatrics | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85072213251&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Acute_human_bocavirus.pdf | 704.46 kB | Adobe PDF | View/Open |
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