Please use this identifier to cite or link to this item:
10.1507/endocrj.EJ18-0396
Title: | Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1β in Hashimoto’s thyroiditis but not in graves’ disease |
Authors: | Zake, Tatjana Skuja, Sandra Kalere, Ieva Konrade, Ilze Groma, Valerija Department of Internal Diseases Institute of Anatomy and Anthropology |
Keywords: | Graves’ disease;Hashimoto’s thyroiditis;Interleukin-17;Interleukin-1β;Interleukin-23;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Endocrinology, Diabetes and Metabolism;Endocrinology;SDG 3 - Good Health and Well-being |
Issue Date: | 2019 |
Citation: | Zake , T , Skuja , S , Kalere , I , Konrade , I & Groma , V 2019 , ' Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1β in Hashimoto’s thyroiditis but not in graves’ disease ' , Endocrine Journal , vol. 66 , no. 5 , pp. 423-430 . https://doi.org/10.1507/endocrj.EJ18-0396 |
Abstract: | T helper (Th) 17 cells and interleukin (IL)-17 play a significant role in the pathogenesis of autoimmune thyroid disease (AITD). However, it has recently become clear that Th17 cells are more heterogeneous and exhibit two different phenotypes, whereas IL-23 and IL-1β are crucial for the generation of pathogenic Th17 lymphocytes. We aimed to investigate the association between IL-17 and Th17-promoting cytokines in AITD by studying the immunoexpression patterns of IL-17, IL-23, and IL-1β in thyroid tissue. Following thyroidectomy, 29 patients with AITD (21 cases of Hashimoto’s thyroiditis (HT) and 8 cases of Graves’ disease (GD)) and 18 patients with colloid goiter, as controls, were enrolled in this study, and immunohistochemistry was performed. The expression level of IL-17 in thyrocytes was significantly higher in HT and GD patients than in colloid goiter patients. Immunopositivity for both IL-23 and IL-1β was significantly increased in HT patients compared to GD and colloid goiter patients. However, no difference was found between IL-23 or IL-1β expression in patients with GD and colloid goiter. A positive correlation between IL-17 and IL-23 as well as IL-17 and IL-1β expression was observed in HT patients (r = 0.574, p = 0.007 and r = 0.461, p = 0.036, respectively). In the GD group, IL-17 was positively correlated with IL-1β (r = 0.817, p = 0.013) but not with IL-23 expression. We found increased IL-23 and IL-1β expression in the HT group but not in the GD group. Furthermore, both interleukins were correlated with IL-17 immunopositivity in thyroid tissue, suggesting that pathogenic Th17-promoting cytokines may play a role in HT pathogenesis. |
Description: | Funding Information: This study was supported in part by the Latvian National Research Program “ BIOM?DICIN? ” No. 5.2.4. Publisher Copyright: © The Japan Endocrine Society. |
DOI: | 10.1507/endocrj.EJ18-0396 |
ISSN: | 0918-8959 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Upregulated_tissue_expression.pdf | 7.24 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.