Please use this identifier to cite or link to this item:
10.3390/medicina55120774
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DC Field | Value | Language |
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dc.contributor.author | Gravelsina, Sabine | - |
dc.contributor.author | Nora-Krukle, Zaiga | - |
dc.contributor.author | Svirskis, Simons | - |
dc.contributor.author | Cunskis, Egils | - |
dc.contributor.author | Murovska, Modra | - |
dc.date.accessioned | 2021-04-12T11:45:01Z | - |
dc.date.available | 2021-04-12T11:45:01Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | Gravelsina , S , Nora-Krukle , Z , Svirskis , S , Cunskis , E & Murovska , M 2019 , ' Presence of B19V in patients with thyroid gland disorders ' , Medicina (Lithuania) , vol. 55 , no. 12 , 774 . https://doi.org/10.3390/medicina55120774 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3755 | - |
dc.description | Funding Information: Funding: This research was supported by the research cooperation project “Beta-herpes viruses (HHV-6, HHV-7) and parvovirus B19 infections as possible risk factors for the development of autoimmune thyroid disease” (SZA cooperation project; grant number 10.0029.4) and by the National Research Programme “Biomedicine for the Public Health” (BIOMEDICINE). Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | Background and Objectives: Viral infections are frequently cited as a major environmental factor implicated in thyroid gland diseases. This work aimed to estimate the presence of B19V infection in patients with thyroid gland disorders. Materials and Methods: Thyroid gland tissue and blood samples of 50 patients with autoimmune thyroid gland diseases (AITDs), 76 patients with non-autoimmune thyroid gland diseases (non-AITDs), and 35 deceased subjects whose histories did not show any autoimmune or thyroid diseases (control group) were enrolled in the study. Virus-specific IgM and IgG were detected using ELISA, and the presence and viral load of B19V in the tissue and blood were detected using PCRs. Results: B19V IgG antibodies were detected in 35/50 AITDs patients and in 51/76 non-AITDs patients, and B19V IgM antibodies were detected in 1/50 patients with AITDs and in none of the 76 patients with non-AITDs. The B19V NS sequence was found in the tissue DNA of 10/50 patients with AITDs, in 30/76 with non-AITDs, and in 1/35 control group individuals. The median B19V load in the tissue of patients with AITDs and non-AITDs was 423.00 copies/µg DNA (IQR: 22.50–756.8) and 43.00 copies/µg DNA (IQR: 11.50–826.5), respectively. The viral load in one of the 35 nPCR B19V-positive thyroid tissue samples from the deceased subjects was 13.82 copies/µg DNA. The viral load in the tissue of patients with AITDs was higher than in whole blood, which possibly indicates B19V persistency in thyrocytes (p = 0.0076). Conclusion: The fact that the genoprevalence of B19V NS was significantly higher in patients with non-AITDs compared to the control group and in the thyroid gland tissue of patients with AITDs, and that the non-AITDs viral load was higher than in tissue derived from the control group individuals, suggest the possibility that B19V infection could be involved in the development of thyroid gland diseases. | en |
dc.format.extent | 1084721 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Medicina (Lithuania) | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | B19V | - |
dc.subject | Thyroid gland diseases | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 3.3 Health sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.title | Presence of B19V in patients with thyroid gland disorders | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/medicina55120774 | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85076222100&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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File | Size | Format | |
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Presence_of_B19V_in_Patients_with_Thyroid_Gland_Disorders.pdf | 1.06 MB | Adobe PDF | View/Open |
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