Please use this identifier to cite or link to this item:
10.1007/s13365-018-0703-8
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DC Field | Value | Language |
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dc.contributor.author | Krumina, Angelika | - |
dc.contributor.author | Chapenko, Svetlana | - |
dc.contributor.author | Kenina, Viktorija | - |
dc.contributor.author | Mihailova, Marija | - |
dc.contributor.author | Logina, Inara | - |
dc.contributor.author | Rasa, Santa | - |
dc.contributor.author | Gintere, Sandra | - |
dc.contributor.author | Viksna, Ludmila | - |
dc.contributor.author | Svirskis, Simons | - |
dc.contributor.author | Murovska, Modra | - |
dc.date.accessioned | 2021-04-12T11:35:01Z | - |
dc.date.available | 2021-04-12T11:35:01Z | - |
dc.date.issued | 2019-04-15 | - |
dc.identifier.citation | Krumina , A , Chapenko , S , Kenina , V , Mihailova , M , Logina , I , Rasa , S , Gintere , S , Viksna , L , Svirskis , S & Murovska , M 2019 , ' The role of HHV-6 and HHV-7 infections in the development of fibromyalgia ' , Journal of NeuroVirology , vol. 25 , no. 2 , pp. 194-207 . https://doi.org/10.1007/s13365-018-0703-8 | - |
dc.identifier.issn | 1355-0284 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3753 | - |
dc.description | Funding Information: Funding The work was supported by the project RSU ZP 13/2013: BAssociation of fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome with beta-herpesviruses (HHV-6A, HHV-6B, HHV-7) and parvovirus B19 infection^ (SC). Publisher Copyright: © 2019, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | Human herpes virus-6 (HHV-6) and human herpes virus-7 (HHV-7) are immunomodulating viruses potentially affecting the nervous system. We evaluated the influence of HHV-6 and HHV-7 infections on fibromyalgia (FM) clinical course. Forty-three FM patients and 50 control group participants were enrolled. 39.50% (n = 17) FM patients had light A delta and C nerve fiber damage, 27.91% (n = 12) had severe A delta and C nerve fiber damage. 67.44% (n = 29) FM patients had loss of warm sensation in feet, loss of heat pain sensation, and increased cold pain sensation (34.90%, n = 15 in both findings). HHV-6 and HHV-7 genomic sequences in peripheral blood DNA in 23/43 (51.00%) and 34/43 (75.50%) of samples from FM patients and in 3/50 (6.00%) and 26/50 (52.00%) of samples from the control group individuals were detected. Active HHV-6 (plasma viremia) or HHV-7 infection was revealed only in FM patients (4/23, 17.40% and 4/34, 11.80%, respectively). A statistically significant moderate positive correlation was found between A delta and C nerve fiber damage severity and HHV-6 infection (p < 0.01, r = 0.410). 23/43 patients from the FM group and control group participants HHV-6 and 34/45 HHV-7 did have infection markers. A statistically significant moderate positive correlation was found between A delta and C nerve fiber damage severity and HHV-6 infection (p < 0.01, r = 0.410). No difference was found between detection frequency of persistent HHV-6 and HHV-7 infection between FM patients and the control group. Statistically significant correlation was observed between quantitation of changes in QST thermal modalities and HHV-6 infection. There was no correlation between A delta and C nerve fiber damage and HHV-7 infection. | en |
dc.format.extent | 14 | - |
dc.format.extent | 2510599 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Journal of NeuroVirology | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Fibromyalgia | - |
dc.subject | HHV-6 | - |
dc.subject | HHV-7 | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Neurology | - |
dc.subject | Clinical Neurology | - |
dc.subject | Cellular and Molecular Neuroscience | - |
dc.subject | Virology | - |
dc.title | The role of HHV-6 and HHV-7 infections in the development of fibromyalgia | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1007/s13365-018-0703-8 | - |
dc.contributor.institution | Department of Infectology | - |
dc.contributor.institution | Department of Neurology and Neurosurgery | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.contributor.institution | Department of Family Medicine | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85059676392&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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The_role_of_HHV_6_and_HHV_7_infections.pdf | 2.45 MB | Adobe PDF | View/Open |
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