Please use this identifier to cite or link to this item:
10.2478/prolas-2019-0018
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Sokolovska, Liba | - |
dc.contributor.author | Sultanova, Alina | - |
dc.contributor.author | Čistjakovs, Maksims | - |
dc.contributor.author | Cunskis, Egils | - |
dc.contributor.author | Murovska, Modra | - |
dc.date.accessioned | 2021-04-12T11:10:03Z | - |
dc.date.available | 2021-04-12T11:10:03Z | - |
dc.date.issued | 2019-05-01 | - |
dc.identifier.citation | Sokolovska , L , Sultanova , A , Čistjakovs , M , Cunskis , E & Murovska , M 2019 , ' Monocytes/macrophages act as mediators for human herpesvirus-6 infection of thyroid gland in patients with autoimmune thyroiditis ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 73 , no. 2 , pp. 112-116 . https://doi.org/10.2478/prolas-2019-0018 | - |
dc.identifier.issn | 1407-009X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3750 | - |
dc.description | Funding Information: This work was supported by the National Research Programme “Biomedicine for the Public Health” (BIOMEDICINE) Publisher Copyright: © 2019 Liba Sokolovska et al., published by Sciendo 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | The aim of this study was to investigate the possibility of using monocytes/macrophages as mediators in human herpesvirus-6 (HHV-6) infection of thyroid gland tissues in autoimmune thyroiditis (AIT). Seventy-three AIT patients were enrolled in this study. The control group consisted of 80 blood donors. Monocyte/macrophage isolation for AIT patient samples was performed by adherence. HHV-6 was detected in peripheral blood mononuclear cell (PBMC) DNA samples using nested polymerase chain reaction (nPCR). Gene expression of HHV-6 active infection marker (U79/80) and chemokine receptors (U12, U51) in patient monocyte/macrophage samples and blood donor PBMC samples was detected using reverse-transcription PCR. HHV-6 viral load was detected by using quantitative-PCR technique. The HHV-6 genomic sequence was found significantly more frequently among AIT patient than control group samples. Markers of active infection were found in 8 AIT patient monocyte/macrophage samples (11%) and in none of control group PBMC samples. HHV-6 U51 mRNA expression was detected only in AIT patient samples (2/24 previously positive for HHV-6). Since HHV-6 genomic sequences were found significantly more frequently in AIT patient samples and active infection markers were found in patient monocytes/macrophages, our results suggest that monocytes/macrophages may be used by HHV-6 as mediators for thyroid gland infection. | en |
dc.format.extent | 5 | - |
dc.format.extent | 281692 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | autoimmunity | - |
dc.subject | HHV-6 | - |
dc.subject | thyroid gland | - |
dc.subject | 1.6 Biological sciences | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General | - |
dc.title | Monocytes/macrophages act as mediators for human herpesvirus-6 infection of thyroid gland in patients with autoimmune thyroiditis | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.2478/prolas-2019-0018 | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85065659922&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Monocytes_Macrophages_Act_as_Mediators_for_Human_Herpesvirus.pdf | 275.09 kB | Adobe PDF | View/Open |
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