Please use this identifier to cite or link to this item:
10.3390/medicina55080496
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DC Field | Value | Language |
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dc.contributor.author | Vitenberga, Zane | - |
dc.contributor.author | Pilmane, Māra | - |
dc.contributor.author | Babjoniševa, Aurika | - |
dc.date.accessioned | 2021-04-12T08:50:01Z | - |
dc.date.available | 2021-04-12T08:50:01Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | Vitenberga , Z , Pilmane , M & Babjoniševa , A 2019 , ' An insight into COPD morphopathogenesis : Chronic inflammation, remodeling, and antimicrobial defense ' , Medicina (Lithuania) , vol. 55 , no. 8 , 496 . https://doi.org/10.3390/medicina55080496 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3739 | - |
dc.description | Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.description.abstract | Background and Objectives: Intercellular signaling networks with high complexity cause a spectrum of mechanisms achieving chronic obstructive pulmonary disease (COPD) that still question many uncertainties. Materials and Methods: Immunoreactive cells in bronchial tissue obtained from 40 COPD patients and 49 healthy control subjects were detected by biotin-streptavidin immunohistochemistry method for the following markers of IL-1α, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, TNF-α, MMP-2, TIMP-2, TGF-β1, Hsp-70, hBD-2, hBD-3, hBD-4. Results: Overall the highest numbers (from mostly moderate (++) to abundance (++++)) of IL-1α, IL-4, IL-7, IL-8, IL-10, IL-12, MMP-2, TIMP-2, TGF-β1 immunoreactive cells were marked increasingly in the blood vessel wall, connective tissue, and bronchial epithelium of COPD-affected lung, respectively. We found statistically significant (p < 0.05) higher numbers of immunoreactive cells positive for all of examined interleukins, TNF-α, MMP-2, TIMP-2, TGF-β1, hBD-2, and hBD-3 in the COPD-affected lung compared to the control group, but not for Hsp-70 and hBD-4. Conclusions: COPD-affected lung tissue exhibits mostly inflammatory response patterns of increased IL-1α, IL-4, IL-8, IL-12, and TNF-α, especially in the airway epithelium. Increased MMP-2 and TGF-β1, but decreased Hsp-70, proposes pronounced tissue damage and remodeling in COPD. High numbers of hBD-2 and hBD-3 immunoreactive cells may highlight antimicrobial activity in COPD within stable regulation of local immunity. | en |
dc.format.extent | 4367882 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Medicina (Lithuania) | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Airways | - |
dc.subject | Chronic inflammation | - |
dc.subject | COPD | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Tissue | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.title | An insight into COPD morphopathogenesis : Chronic inflammation, remodeling, and antimicrobial defense | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/medicina55080496 | - |
dc.contributor.institution | Department of Morphology | - |
dc.contributor.institution | Institute of Anatomy and Anthropology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85071507757&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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An_insight_into_COPD.pdf | 4.27 MB | Adobe PDF | View/Open |
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