Please use this identifier to cite or link to this item:
10.3390/jpm14090965
Title: | Characterization of local tissue immunity defence factors of the lip in primary dentition children with bilateral cleft lip palate |
Authors: | Ozola, Laura Pilmane, Māra Institute of Anatomy and Anthropology |
Keywords: | cleft lip and palate;tissue defense factors;primary dentition;HBD;IL;Gal-10;CD-163;3.1 Basic medicine;1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions) |
Issue Date: | 2024 |
Citation: | Ozola , L & Pilmane , M 2024 , ' Characterization of local tissue immunity defence factors of the lip in primary dentition children with bilateral cleft lip palate ' , Journal of Personalized Medicine , vol. 14 , no. 9 , 965 , pp. 1-25 . https://doi.org/10.3390/jpm14090965 |
Abstract: | Background: Bilateral cleft lip palate is a severe congenital birth defect of the mouth and face. Immunity factors modulate immune response, inflammation, and healing; therefore, they are vital in the assessment of the immunological status of the patient. The aim of this study is to assess the distribution of Gal-10, CD-163, IL-4, IL-6, IL-10, HBD-2, HBD-3, and HBD-4 in tissue of the bilateral cleft lip palate in primary dentition children. Methods: Five patients underwent cheiloplasty surgery, where five tissue samples of lip were obtained. Immunohistochemical staining, semi-quantitative evaluation, and non-parametric statistical analysis were used. Results: A statistically significant increase in HBD-2, HBD-3, and HBD-4 was found in skin and mucosal epithelium, hair follicles, and blood vessels. A notable increase was also noted in IL-4, IL-6, and IL-10 in the mucosal epithelium and CD163 in blood vessels. The connective tissue of patients presented with a statistically significant decrease in Gal-10, IL-10, and HBD-3. Spearman’s rank correlation revealed multiple significant positive and negative correlations between the factors. Conclusions: Upregulation of CD163 points to increased angiogenesis but the increase in IL-4 and IL-10 as well as the decrease in Gal-10 points to suppression of excessive inflammatory damage. Decreased connective tissue healing and excessive scarring are suggested by the decrease in HBD-3 and IL-10 and the increase in IL-6. |
DOI: | 10.3390/jpm14090965 |
ISSN: | 2075-4426 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Characterization_of_Tissue_Immunity_Defense_Factors_of_the_Lip.pdf | 9.98 MB | Adobe PDF | View/Open |
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