Diētas ietekme uz zvīņēdes (Psoriasis vulgaris) uzliesmojumiem un terapijas efektivitāti
No Thumbnail Available
Date
2024
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Pasaules Veselības organizācija psoriasis vulgaris ir klasificējusi kā vienu no
nopietnākajām neinfekciozajām slimībām. Psoriāze skar vismaz 125 miljonus cilvēku visā
pasaulē, un tās izplatība ir vienāda gan vīriešu, gan sieviešu vidū. Prevalence atšķiras atkarībā
no reģiona – tā svārstās no 0,09% līdz pat 11,43%. Latvijā psoriasis vulgaris izplatība ir 2,2
gadījumi uz 100000 iedzīvotāju gadā.
Psoriāzes patoģenēzi ietekmē ģenētiskā predispozīcija un vides faktori, tostarp
infekcijas, stress un uzturs. Galvenā nozīme tās attīstībā ir adaptīvās imūnsistēmas
komponentu pārmērīgai aktivizācijai, kurā galvenā loma ir tādiem citokīniem kā TNF-α, IL12, IL-17 un IL-23, kas pacientiem izraisa paaugstinātu proiekaisuma citokīnu līmeni.
Ņemot vērā psoriāzes multifaktoriālo etioloģiju, kas ietver ģenētiskus, imunoloģiskus
un vides faktorus, arvien vairāk tiek atzīta papildu terapijas nozīme. Šo nefarmakoloģisko
pieeju mērķis ir papildināt tradicionālo ārstēšanu, potenciāli mazinot blakusparādības un
uzlabojot vispārējo terapijas efektivitāti. Par vērtīgām stratēģijām ir kļuvušas dzīvesveida
maiņa, tostarp diētas izmaiņas un stresa pārvaldība. Kombinējot šīs papildu stratēģijas ar
tradicionālo ārstēšanu, ir iespējams panākt labāku pacientu dzīves kvalitāti, samazinot
psoriāzes un ar to saistīto blakusslimību slogu.
Mērķis šim literatūras apskatam bija aprakstīt kā diēta var ietekmēt psoriāzes terapiju
un slimības uzliesmojumus.
Pētījuma gaitā tika atlasītas un analizētas zinātniskās publikācijas un elektroniskās
grāmatas tādās datu bāzēs kā: EBSCO host, PubMed, ScienceDirect, ClinicalKey, Access
Medicine.
Literatūras apskata rezultātā tika secināts, ka psoriāzes farmakoloģisko ārstēšanu var
papildināt ar uztura komponentiem, kas rada sistēmisku pretiekaisuma iedarbību. Tas var
labvēlīgi ietekmēt psoriāzes gaitu un veicināt iekaisuma mazināšanu, kā arī palīdz risināt ar
psoriāzi bieži saistītās blakusslimības, piemēram, aptaukošanos, sirds un asinsvadu slimības
un metabolo sindromu.
Pašlaik psoriāzi nav iespējams izārstēt. Ārstēšanas mērķis ir simptomu kontrole,
saslimstības kontrole un papildu blakusslimību profilakse. Ir nepieciešama holistiska pieeja
un tādu specialitāšu, kā dermotologu un uztura speciālistu, sadarbība, lai uzlabotu psoriāzes
pacientu dzīves kvalitāti.
Psoriasis vulgaris is classified by the World Health Organization as one of the most serious non-communicable diseases. Psoriasis affects at least 125 million people worldwide, and its spread is the same among men and women. The prevalence varies by region, ranging from 0.09% to 11.43%. In Latvia, the prevalence of psoriasis vulgaris is 2.2 cases per 100,000 residents per year. The pathogenesis of psoriasis is influenced by genetic predisposition and environmental factors, including infections, stress and diet. Over-activation of components of the adaptive immune system, in which cytokines such as TNF-α, IL-12, IL-17 and IL-23 play a key role, leads to increased levels of pro-inflammatory cytokines in patients. Given the multifactorial aetiology of psoriasis, involving genetic, immunological and environmental factors, the role of complementary therapies is increasingly recognized. These non-pharmacological approaches aim to complement conventional treatments, potentially reducing side effects and improving the overall efficacy of therapy. Lifestyle changes, including dietary changes and stress management, have become valuable strategies. Combining these complementary strategies with conventional treatments can lead to a better quality of life for patients, reducing the burden of psoriasis and associated co-morbidities. The aim of this literature review was to describe how diet can influence psoriasis treatment and flares. Scientific publications and electronic books were selected and analyzed in databases such as EBSCO host, PubMed, ScienceDirect, ClinicalKey, Access Medicine. The literature review showed that pharmacological treatment of psoriasis can be supplemented with dietary components that exert systemic anti-inflammatory effects. This may have a beneficial effect on the course of psoriasis and contribute to reducing inflammation, as well as helping to address co-morbidities commonly associated with psoriasis, such as obesity, cardiovascular disease and metabolic syndrome. There is currently no cure for psoriasis. Treatment aims to control symptoms, control incidence and prevent additional co-morbidities. A holistic approach and collaboration between specialties such as dermatologist's and nutritionists is needed to improve the quality of life of psoriasis patients.
Psoriasis vulgaris is classified by the World Health Organization as one of the most serious non-communicable diseases. Psoriasis affects at least 125 million people worldwide, and its spread is the same among men and women. The prevalence varies by region, ranging from 0.09% to 11.43%. In Latvia, the prevalence of psoriasis vulgaris is 2.2 cases per 100,000 residents per year. The pathogenesis of psoriasis is influenced by genetic predisposition and environmental factors, including infections, stress and diet. Over-activation of components of the adaptive immune system, in which cytokines such as TNF-α, IL-12, IL-17 and IL-23 play a key role, leads to increased levels of pro-inflammatory cytokines in patients. Given the multifactorial aetiology of psoriasis, involving genetic, immunological and environmental factors, the role of complementary therapies is increasingly recognized. These non-pharmacological approaches aim to complement conventional treatments, potentially reducing side effects and improving the overall efficacy of therapy. Lifestyle changes, including dietary changes and stress management, have become valuable strategies. Combining these complementary strategies with conventional treatments can lead to a better quality of life for patients, reducing the burden of psoriasis and associated co-morbidities. The aim of this literature review was to describe how diet can influence psoriasis treatment and flares. Scientific publications and electronic books were selected and analyzed in databases such as EBSCO host, PubMed, ScienceDirect, ClinicalKey, Access Medicine. The literature review showed that pharmacological treatment of psoriasis can be supplemented with dietary components that exert systemic anti-inflammatory effects. This may have a beneficial effect on the course of psoriasis and contribute to reducing inflammation, as well as helping to address co-morbidities commonly associated with psoriasis, such as obesity, cardiovascular disease and metabolic syndrome. There is currently no cure for psoriasis. Treatment aims to control symptoms, control incidence and prevent additional co-morbidities. A holistic approach and collaboration between specialties such as dermatologist's and nutritionists is needed to improve the quality of life of psoriasis patients.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
psoriāze, diēta, uzturs, sistēmiskā slimība, pretiekaisuma prātikas produkti., psoriasis, diet, nutrition, systemic disease, anti-inflammatory foods.