Please use this identifier to cite or link to this item:
10.1097/INF.0000000000004267
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DC Field | Value | Language |
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dc.contributor.author | Yeoh, Sophya | - |
dc.contributor.author | Estrada-Rivadeneyra, Diego | - |
dc.contributor.author | Jackson, Heather | - |
dc.contributor.author | Zavadska, Dace | - |
dc.contributor.author | PERFORM, DIAMONDS and UK KD Genetic Consortia | - |
dc.date.accessioned | 2024-05-14T07:40:01Z | - |
dc.date.available | 2024-05-14T07:40:01Z | - |
dc.date.issued | 2024-05-01 | - |
dc.identifier.citation | Yeoh , S , Estrada-Rivadeneyra , D , Jackson , H , Zavadska , D & PERFORM, DIAMONDS and UK KD Genetic Consortia 2024 , ' Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases ' , The Pediatric infectious disease journal , vol. 43 , no. 5 , pp. 444-453 . https://doi.org/10.1097/INF.0000000000004267 | - |
dc.identifier.issn | 0891-3668 | - |
dc.identifier.other | PubMedCentral: PMC11003410 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/15484 | - |
dc.description | Publisher Copyright: © 2024 Lippincott Williams and Wilkins. All rights reserved. | - |
dc.description.abstract | BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious hyperinflammatory complication following infection with severe acute respiratory syndrome coronavirus 2. The mechanisms underpinning the pathophysiology of MIS-C are poorly understood. Moreover, clinically distinguishing MIS-C from other childhood infectious and inflammatory conditions, such as Kawasaki disease or severe bacterial and viral infections, is challenging due to overlapping clinical and laboratory features. We aimed to determine a set of plasma protein biomarkers that could discriminate MIS-C from those other diseases. METHODS: Seven candidate protein biomarkers for MIS-C were selected based on literature and from whole blood RNA sequencing data from patients with MIS-C and other diseases. Plasma concentrations of ARG1, CCL20, CD163, CORIN, CXCL9, PCSK9 and ADAMTS2 were quantified in MIS-C (n = 22), Kawasaki disease (n = 23), definite bacterial (n = 28) and viral (n = 27) disease and healthy controls (n = 8). Logistic regression models were used to determine the discriminatory ability of individual proteins and protein combinations to identify MIS-C and association with severity of illness. RESULTS: Plasma levels of CD163, CXCL9 and PCSK9 were significantly elevated in MIS-C with a combined area under the receiver operating characteristic curve of 85.7% (95% confidence interval: 76.6%-94.8%) for discriminating MIS-C from other childhood diseases. Lower ARG1 and CORIN plasma levels were significantly associated with severe MIS-C cases requiring inotropes, pediatric intensive care unit admission or with shock. CONCLUSION: Our findings demonstrate the feasibility of a host protein biomarker signature for MIS-C and may provide new insight into its pathophysiology. | en |
dc.format.extent | 10 | - |
dc.format.extent | 805605 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | The Pediatric infectious disease journal | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Humans | - |
dc.subject | Child | - |
dc.subject | Proprotein Convertase 9 | - |
dc.subject | Mucocutaneous Lymph Node Syndrome/diagnosis | - |
dc.subject | Blood Proteins | - |
dc.subject | Systemic Inflammatory Response Syndrome/diagnosis | - |
dc.subject | Biomarkers | - |
dc.subject | COVID-19/complications | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.title | Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1097/INF.0000000000004267 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85191105993&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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File | Size | Format | |
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Plasma_Protein_Biomarkers_Distinguish_Multisystem.pdf | 786.72 kB | Adobe PDF | View/Open |
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