Please use this identifier to cite or link to this item:
10.3390/pharmaceutics16050586
Title: | Taste-Masked Pellets of Warfarin Sodium : Formulation towards the Dose Personalisation |
Authors: | Kovalenko, Lakija Kukuls, Kirils Berga, Marta Mohylyuk, Valentyn Laboratory of Finished Dosage Forms |
Keywords: | warfarin;pellets;taste;taste masking;cores;microcrystalline cellulose;dibasic calcium phosphate;sodium chloride;Kollicoat® Smartseal;dibutyl sebacate;salting-out effect;1.4 Chemical sciences;2.4 Chemical engineering;2.5 Materials engineering;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | May-2024 |
Citation: | Kovalenko , L , Kukuls , K , Berga , M & Mohylyuk , V 2024 , ' Taste-Masked Pellets of Warfarin Sodium : Formulation towards the Dose Personalisation ' , Pharmaceutics , vol. 16 , no. 5 , 586 . https://doi.org/10.3390/pharmaceutics16050586 |
Abstract: | The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to improve patient compliance, as well as to investigate the effect of the core type (PharSQ® Spheres M, CELPHERE™ CP-507, and NaCl) on the warfarin release from the Kollicoat® Smartseal taste-masking-coated pellets. The cores were successfully drug-loaded and coated in a fluid-bed coater with a Wurster insert. An increase in particle size and particle size distribution was observed by optical microscopy. In saliva-simulated pH, at the Kollicoat® Smartseal level of 2 mg/cm2, none of the pellets demonstrated drug release, confirming their efficient taste-masking. However, in a stomach-simulated pH, a faster drug release was observed from PharSQ® Spheres M- and CELPHERE™ CP-507-coated pellets in comparison with NaCl cores. Additional experiments allowed us to explain the slower drug release from NaCl-containing pellets because of the salting-out effect. Despite the successful taste masking, the drug release from pellets was relatively slow (not more than 91% per 60 min), allowing for further formulation improvements. |
Description: | Publisher Copyright: © 2024 by the authors. |
DOI: | 10.3390/pharmaceutics16050586 |
ISSN: | 1999-4923 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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pharmaceutics-16-00586.pdf | 13.53 MB | Adobe PDF | View/Open |
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