Taste-Masked Pellets of Warfarin Sodium : Formulation towards the Dose Personalisation

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dc.contributor.authorKovalenko, Lakija
dc.contributor.authorKukuls, Kirils
dc.contributor.authorBerga, Marta
dc.contributor.authorMohylyuk, Valentyn
dc.contributor.institutionLaboratory of Finished Dosage Forms
dc.date.accessioned2024-05-03T09:10:04Z
dc.date.available2024-05-03T09:10:04Z
dc.date.issued2024-05
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractThe bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to improve patient compliance, as well as to investigate the effect of the core type (PharSQ® Spheres M, CELPHERE™ CP-507, and NaCl) on the warfarin release from the Kollicoat® Smartseal taste-masking-coated pellets. The cores were successfully drug-loaded and coated in a fluid-bed coater with a Wurster insert. An increase in particle size and particle size distribution was observed by optical microscopy. In saliva-simulated pH, at the Kollicoat® Smartseal level of 2 mg/cm2, none of the pellets demonstrated drug release, confirming their efficient taste-masking. However, in a stomach-simulated pH, a faster drug release was observed from PharSQ® Spheres M- and CELPHERE™ CP-507-coated pellets in comparison with NaCl cores. Additional experiments allowed us to explain the slower drug release from NaCl-containing pellets because of the salting-out effect. Despite the successful taste masking, the drug release from pellets was relatively slow (not more than 91% per 60 min), allowing for further formulation improvements.en
dc.description.statusPeer reviewed
dc.format.extent13853140
dc.identifier.citationKovalenko, L, Kukuls, K, Berga, M & Mohylyuk, V 2024, 'Taste-Masked Pellets of Warfarin Sodium : Formulation towards the Dose Personalisation', Pharmaceutics, vol. 16, no. 5, 586. https://doi.org/10.3390/pharmaceutics16050586
dc.identifier.doi10.3390/pharmaceutics16050586
dc.identifier.issn1999-4923
dc.identifier.otherMendeley: dce5455a-7242-3ec8-b38c-94fecc53e4dc
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15463
dc.identifier.urlhttps://www.mendeley.com/catalogue/dce5455a-7242-3ec8-b38c-94fecc53e4dc/
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85194384486&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPharmaceutics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectwarfarin
dc.subjectpellets
dc.subjecttaste
dc.subjecttaste masking
dc.subjectcores
dc.subjectmicrocrystalline cellulose
dc.subjectdibasic calcium phosphate
dc.subjectsodium chloride
dc.subjectKollicoat® Smartseal
dc.subjectdibutyl sebacate
dc.subjectsalting-out effect
dc.subject1.4 Chemical sciences
dc.subject2.4 Chemical engineering
dc.subject2.5 Materials engineering
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleTaste-Masked Pellets of Warfarin Sodium : Formulation towards the Dose Personalisationen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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