Please use this identifier to cite or link to this item:
10.1038/s41598-024-58850-w
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DC Field | Value | Language |
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dc.contributor.author | Maldupa, Ilze | - |
dc.contributor.author | Innes, Nicola | - |
dc.contributor.author | Viduskalne, Ilona | - |
dc.contributor.author | Brinkmane, Anda | - |
dc.contributor.author | Senakola, Egita | - |
dc.contributor.author | Krūmiņa, Karīna | - |
dc.contributor.author | Uribe, Sergio E | - |
dc.date.accessioned | 2024-04-16T07:30:01Z | - |
dc.date.available | 2024-04-16T07:30:01Z | - |
dc.date.issued | 2024-04-07 | - |
dc.identifier.citation | Maldupa , I , Innes , N , Viduskalne , I , Brinkmane , A , Senakola , E , Krūmiņa , K & Uribe , S E 2024 , ' Clinical effectiveness/child-patient and parent satisfaction of two topical fluoride treatments for caries : a randomised clinical trial ' , Scientific Reports , vol. 14 , no. 1 , 8123 , pp. 1-11 . https://doi.org/10.1038/s41598-024-58850-w | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | PubMedCentral: PMC10998894 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/15432 | - |
dc.description | Publisher Copyright: © The Author(s) 2024. | - |
dc.description.abstract | Knowledge gaps exist regarding optimal silver diammine fluoride (SDF) regimens and the efficacy of new products for arresting dental caries in young children. We evaluated the effectiveness of 38%-SDF (SDI-RivaStar), Tiefenfluorid (TF) comparing with Placebo (P), all in conjunction with behavioural modification (BM), in preventing major complications (endodontic/extractions/pain)-a patient-centred outcome-due to early childhood caries over 12 months in children under 71-months. A six-arm, patient/parent-blinded, superiority, placebo-controlled randomised control trial at the university clinic in Riga, Latvia, from 1/9/20-31/8/22 (Protocol registration ISRCTN17005348). The trial tested six protocols, using three compounds (P/SDF/TF) under two regimes: annual and biannual (P1/P2/TF1/TF2/SDF1/SDF2) for major complications. Secondary outcomes included minor complications and parental satisfaction. All groups received BM. 373/427 randomised children (87.3%) completed the study. SDF2 had a significantly lower rate and risk of major (21.5%, OR = 0.28, 95%CI [0.11, 0.72], p < 0.05) and minor complications (OR = 0.16 (95%CI [0.05, 0.50], p = 0.002). Overall satisfaction was 96% (p > 0.05). SDF biannual application with BM effectively prevented major complications of early childhood caries and was well accepted by children and their parents. Trial registration number: ISRCTN17005348, principal investigator: Ilze Maldupa, registration date: 30/06/2021.Clinical trial registration number: ISRCTN registry: ISRCTN17005348, https://doi.org/10.1186/ISRCTN17005348 , registration date: 30/06/2021. | en |
dc.format.extent | 11 | - |
dc.format.extent | 3283506 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Humans | - |
dc.subject | Child, Preschool | - |
dc.subject | Cariostatic Agents/therapeutic use | - |
dc.subject | Fluoride Treatment | - |
dc.subject | Dental Caries/prevention & control | - |
dc.subject | Dental Caries Susceptibility | - |
dc.subject | Patient Satisfaction | - |
dc.subject | Fluorides, Topical/therapeutic use | - |
dc.subject | Treatment Outcome | - |
dc.subject | Silver Compounds/therapeutic use | - |
dc.subject | Quaternary Ammonium Compounds/therapeutic use | - |
dc.subject | Parents | - |
dc.subject | Personal Satisfaction | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.title | Clinical effectiveness/child-patient and parent satisfaction of two topical fluoride treatments for caries : a randomised clinical trial | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1038/s41598-024-58850-w | - |
dc.contributor.institution | Department of Conservative Dentistry and Oral Health | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85189312631&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Artificial_intelligence_chatbots_and_large_language_models.pdf | 3.21 MB | Adobe PDF | View/Open |
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