Please use this identifier to cite or link to this item:
10.3390/microorganisms12020362
Title: | From Viral Infection to Autoimmune Reaction : Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases |
Authors: | Sokolovska, Liba Cistjakovs, Maksims Matroze, Asnate Murovska, Modra Sultanova, Alina Institute of Microbiology and Virology |
Keywords: | HHV-6;human herpesvirus 6;autoimmunity;autoimmune disease;multiple sclerosis;systemic sclerosis;inflammatory bowel disease;autoimmune thyroiditis;chronic fatigue syndrome;3.3 Health sciences;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;SDG 3 - Good Health and Well-being |
Issue Date: | 9-Feb-2024 |
Citation: | Sokolovska , L , Cistjakovs , M , Matroze , A , Murovska , M & Sultanova , A 2024 , ' From Viral Infection to Autoimmune Reaction : Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases ' , Microorganisms , vol. 12 , no. 2 , 362 , pp. 1-18 . https://doi.org/10.3390/microorganisms12020362 , https://doi.org/10.3390/microorganisms12020362 |
Abstract: | The complexity of autoimmunity initiation has been the subject of many studies. Both genetic and environmental factors are essential in autoimmunity development. Among others, environmental factors include infectious agents. HHV-6 is a ubiquitous human pathogen with a high global prevalence. It has several properties suggestive of its contribution to autoimmunity development. HHV-6 has a broad cell tropism, the ability to establish latency with subsequent reactivation and persistence, and a range of immunomodulation capabilities. Studies have implicated HHV-6 in a plethora of autoimmune diseases-endocrine, neurological, connective tissue, and others-with some studies even proposing possible autoimmunity induction mechanisms. HHV-6 can be frequently found in autoimmunity-affected tissues and lesions; it has been found to infect autoimmune-pathology-relevant cells and influence immune responses and signaling. This review highlights some of the most well-known autoimmune conditions to which HHV-6 has been linked, like multiple sclerosis and autoimmune thyroiditis, and summarizes the data on HHV-6 involvement in autoimmunity development. |
Description: | Publisher Copyright: © 2024 by the authors. |
DOI: | 10.3390/microorganisms12020362 |
ISSN: | 2076-2607 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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From_Viral_Infection_to_Autoimmune_Reaction.pdf | 1.26 MB | Adobe PDF | View/Open |
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