From Viral Infection to Autoimmune Reaction : Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases

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dc.contributor.authorSokolovska, Lība
dc.contributor.authorČistjakovs, Maksims
dc.contributor.authorMatroze, Asnate
dc.contributor.authorMurovska, Modra
dc.contributor.authorSultanova, Alīna
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2024-03-22T08:55:01Z
dc.date.available2024-03-22T08:55:01Z
dc.date.issued2024-02-09
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractThe complexity of autoimmunity initiation has been the subject of many studies. Both genetic and environmental factors are essential in autoimmunity development. Among others, environmental factors include infectious agents. HHV-6 is a ubiquitous human pathogen with a high global prevalence. It has several properties suggestive of its contribution to autoimmunity development. HHV-6 has a broad cell tropism, the ability to establish latency with subsequent reactivation and persistence, and a range of immunomodulation capabilities. Studies have implicated HHV-6 in a plethora of autoimmune diseases-endocrine, neurological, connective tissue, and others-with some studies even proposing possible autoimmunity induction mechanisms. HHV-6 can be frequently found in autoimmunity-affected tissues and lesions; it has been found to infect autoimmune-pathology-relevant cells and influence immune responses and signaling. This review highlights some of the most well-known autoimmune conditions to which HHV-6 has been linked, like multiple sclerosis and autoimmune thyroiditis, and summarizes the data on HHV-6 involvement in autoimmunity development.en
dc.description.statusPeer reviewed
dc.format.extent18
dc.format.extent1294143
dc.identifier.citationSokolovska, L, Čistjakovs, M, Matroze, A, Murovska, M & Sultanova, A 2024, 'From Viral Infection to Autoimmune Reaction : Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases', Microorganisms, vol. 12, no. 2, 362, pp. 1-18. https://doi.org/10.3390/microorganisms12020362, https://doi.org/10.3390/microorganisms12020362
dc.identifier.doi10.3390/microorganisms12020362
dc.identifier.issn2076-2607
dc.identifier.otherPubMedCentral: PMC10892088
dc.identifier.otherunpaywall: 10.3390/microorganisms12020362
dc.identifier.otherMendeley: 8abe9c97-fcde-3d1f-b39f-d02cb1d156a6
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15394
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85187261458&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMicroorganisms
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHHV-6
dc.subjecthuman herpesvirus 6
dc.subjectautoimmunity
dc.subjectautoimmune disease
dc.subjectmultiple sclerosis
dc.subjectsystemic sclerosis
dc.subjectinflammatory bowel disease
dc.subjectautoimmune thyroiditis
dc.subjectchronic fatigue syndrome
dc.subject3.3 Health sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleFrom Viral Infection to Autoimmune Reaction : Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseasesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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