Please use this identifier to cite or link to this item:
10.3390/jcm12237364
Title: | Assessing the Effects of 0.3% Carboxymethylcellulose Tear Substitute Treatment on Symptoms and Signs of Dry Eye Disease in Elderly Population : A Prospective Longitudinal Study |
Authors: | Ballesteros-Sánchez, Antonio Sánchez-González, José María Tedesco, Giovanni Roberto Rocha-De-Lossada, Carlos Murano, Gianluca Spinelli, Antonio Borroni, Davide Department of Ophthalmology |
Keywords: | artificial tears;carboxymethylcellulose (CMC);dry eye disease (DED);meibomian gland dysfunction (MGD);tear substitutes;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine |
Issue Date: | Dec-2023 |
Citation: | Ballesteros-Sánchez , A , Sánchez-González , J M , Tedesco , G R , Rocha-De-Lossada , C , Murano , G , Spinelli , A & Borroni , D 2023 , ' Assessing the Effects of 0.3% Carboxymethylcellulose Tear Substitute Treatment on Symptoms and Signs of Dry Eye Disease in Elderly Population : A Prospective Longitudinal Study ' , Journal of clinical medicine , vol. 12 , no. 23 , 7364 . https://doi.org/10.3390/jcm12237364 |
Abstract: | Background: We aimed to evaluate the effects of 0.3% carboxymethylcellulose (CMC) tear substitute treatment in dry eye disease (DED), as well as treatment compliance and adverse events (AEs). Methods: In this prospective, longitudinal study, a total of 30 eyes receiving 0.3% CMC tear substitute four times daily for DED were evaluated. Clinical endpoints included an ocular surface disease index (OSDI) questionnaire, average non-invasive tear film break-up time (A-NIBUT), lipid layer thickness (LLT), and a Schirmer test with anesthesia (ST). Treatment compliance and AEs were also assessed. All evaluations were performed at 2, 4, and 12 weeks of follow-up. Results: At the end of the follow-up, significant improvement was observed in all clinical endpoints with the following mean values: ΔOSDI questionnaire of −22.53 ± 14.68 points, ΔA-NIBUT of 4.81 ± 2.88 s, ΔLLT of 5.63 ± 6.53 nm, and ΔST of 2.8 ± 2.1 mm (p < 0.001 for all comparisons). Although repeated measures analysis showed that all clinical endpoints presented statistically significant differences (p < 0.001 for all comparisons LLTBaseline–LLT2-weeks (p = 0.460) and LLT4-weeks–LLT12-weeks (p = 0.071) were the only pairs of measures that reported non-statistically significant differences). In addition, treatment compliance was 94.3 ± 5.2% and transient AEs related to the use of 0.3% CMC tear substitute were reported. Conclusions: 0.3% CMC tear substitute treatment seems to achieve beneficial effects on the OSDI questionnaire, A-NIBUT, LLT, and ST. However, further studies at this concentration are needed to confirm these results. |
Description: | Publisher Copyright: © 2023 by the authors. |
DOI: | 10.3390/jcm12237364 |
ISSN: | 2077-0383 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Assessing_the_Effects.pdf | 285.79 kB | Adobe PDF | View/Open |
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