Assessing the Effects of 0.3% Carboxymethylcellulose Tear Substitute Treatment on Symptoms and Signs of Dry Eye Disease in Elderly Population : A Prospective Longitudinal Study

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dc.contributor.authorBallesteros-Sánchez, Antonio
dc.contributor.authorSánchez-González, José María
dc.contributor.authorTedesco, Giovanni Roberto
dc.contributor.authorRocha-De-Lossada, Carlos
dc.contributor.authorMurano, Gianluca
dc.contributor.authorSpinelli, Antonio
dc.contributor.authorBorroni, Davide
dc.contributor.institutionDepartment of Ophthalmology
dc.date.accessioned2024-02-26T11:20:01Z
dc.date.available2024-02-26T11:20:01Z
dc.date.issued2023-12
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractBackground: We aimed to evaluate the effects of 0.3% carboxymethylcellulose (CMC) tear substitute treatment in dry eye disease (DED), as well as treatment compliance and adverse events (AEs). Methods: In this prospective, longitudinal study, a total of 30 eyes receiving 0.3% CMC tear substitute four times daily for DED were evaluated. Clinical endpoints included an ocular surface disease index (OSDI) questionnaire, average non-invasive tear film break-up time (A-NIBUT), lipid layer thickness (LLT), and a Schirmer test with anesthesia (ST). Treatment compliance and AEs were also assessed. All evaluations were performed at 2, 4, and 12 weeks of follow-up. Results: At the end of the follow-up, significant improvement was observed in all clinical endpoints with the following mean values: ΔOSDI questionnaire of −22.53 ± 14.68 points, ΔA-NIBUT of 4.81 ± 2.88 s, ΔLLT of 5.63 ± 6.53 nm, and ΔST of 2.8 ± 2.1 mm (p < 0.001 for all comparisons). Although repeated measures analysis showed that all clinical endpoints presented statistically significant differences (p < 0.001 for all comparisons LLTBaseline–LLT2-weeks (p = 0.460) and LLT4-weeks–LLT12-weeks (p = 0.071) were the only pairs of measures that reported non-statistically significant differences). In addition, treatment compliance was 94.3 ± 5.2% and transient AEs related to the use of 0.3% CMC tear substitute were reported. Conclusions: 0.3% CMC tear substitute treatment seems to achieve beneficial effects on the OSDI questionnaire, A-NIBUT, LLT, and ST. However, further studies at this concentration are needed to confirm these results.en
dc.description.statusPeer reviewed
dc.format.extent292647
dc.identifier.citationBallesteros-Sánchez, A, Sánchez-González, J M, Tedesco, G R, Rocha-De-Lossada, C, Murano, G, Spinelli, A & Borroni, D 2023, 'Assessing the Effects of 0.3% Carboxymethylcellulose Tear Substitute Treatment on Symptoms and Signs of Dry Eye Disease in Elderly Population : A Prospective Longitudinal Study', Journal of clinical medicine, vol. 12, no. 23, 7364. https://doi.org/10.3390/jcm12237364
dc.identifier.doi10.3390/jcm12237364
dc.identifier.issn2077-0383
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15332
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85179368078&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of clinical medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectartificial tears
dc.subjectcarboxymethylcellulose (CMC)
dc.subjectdry eye disease (DED)
dc.subjectmeibomian gland dysfunction (MGD)
dc.subjecttear substitutes
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleAssessing the Effects of 0.3% Carboxymethylcellulose Tear Substitute Treatment on Symptoms and Signs of Dry Eye Disease in Elderly Population : A Prospective Longitudinal Studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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