Please use this identifier to cite or link to this item: 10.31557/APJCP.2023.24.3.915
Title: Association between Mortality Due to Nasopharyngeal Carcinoma and Race in the United States from 2007 to 2016
Authors: Raslan, Shahm
Rodriguez, Edwin
Zheng, Chengcheng
Lozanoa, Juan
Barengo, Noël C.
Sargi, Zoukaa
Keywords: asians and pacific islanders;effect modifier;insurance status;Nasopharyngeal carcinoma;survival;3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Epidemiology;Oncology;Public Health, Environmental and Occupational Health;Cancer Research;SDG 3 - Good Health and Well-being
Issue Date: 2023
Citation: Raslan , S , Rodriguez , E , Zheng , C , Lozanoa , J , Barengo , N C & Sargi , Z 2023 , ' Association between Mortality Due to Nasopharyngeal Carcinoma and Race in the United States from 2007 to 2016 ' , Asian Pacific Journal of Cancer Prevention , vol. 24 , no. 3 , pp. 915-921 . https://doi.org/10.31557/APJCP.2023.24.3.915
Abstract: Background: Asians and Pacific Islanders (API) exhibit increased incidence of nasopharyngeal carcinoma (NPC). However, they are often excluded when the disease is studied. Risk-factors and incidence are well-researched while cancer-specific mortality trends remain unclear. We aimed to determine whether insurance status modifies the association between race and cancer-specific mortality in NPC patients. Methods: This retrospective cohort study used secondary data analysis from the Surveillance, Epidemiology, and End Results Program database. Patients ≥18 years with histologically confirmed primary NPC from 2007 - 2016 were included. The main outcome assessed was 5-year survival and the main exposure variable was race (API, white, black). Insurance status was classified into uninsured, any Medicaid, and insured (with any insurance). Potential confounders included age, sex, marital status, stage at diagnosis, and surgical treatment. Adjusted Cox regression analysis was used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (CI). Results: 1610 patients were included (72.98% male, 27.02% female). 49.8% were API, 40.5% were Whites, and 9.8% Blacks. Maximum follow-up was 5-years. The adjusted hazards of 5-year cancer-specific death for API and Blacks compared with Whites were 0.77 (95% CI 0.62 – 0.96) and 0.92 (95% CI 0.65 – 1.31), respectively. Cases decreased with age in API and Blacks. 8.2% of cases had localized disease, 45.3% had local spread, and 44.6% had distant metastasis. Insurance status did not modify the association between race and mortality. Conclusion: Race is an important prognostic factor to account for in NPC patients.
Description: Publisher Copyright: © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License
DOI: 10.31557/APJCP.2023.24.3.915
ISSN: 1513-7368
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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