Please use this identifier to cite or link to this item:
10.15388/Amed.2023.30.1.5
Title: | Eosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvement |
Authors: | Panina, Aleksandra Ligere, Elīna Aleksejeva, Elīna Davidsone, Zane Cebure, Elizabete Erdmane, Irina Department of Paediatrics |
Keywords: | Churg–Strauss syn-drome;eosinophilic myocarditis;orbital involvement;paediatric hypereosinophilic syndrome;stroke;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine |
Issue Date: | 24-Jan-2023 |
Citation: | Panina , A , Ligere , E , Aleksejeva , E , Davidsone , Z , Cebure , E & Erdmane , I 2023 , ' Eosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvement ' , Acta medica Lituanica , vol. 30 , no. 1 , pp. 45-52 . https://doi.org/10.15388/Amed.2023.30.1.5 |
Abstract: | Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by peripheral blood eosinophilia of 1.5 × 109/L (1,500/μL) or greater, with evidence of end-organ damage attributable to eosinophilia (e.g., heart, liver or lung) with no other cause for the end-organ damage [1]. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disorder that may affect multiple organ systems (lungs, heart, kidneys, or the nervous system). The disorder is characterized by hypereosinophilia in the blood and tis-sues, inflammation of blood vessels (vasculitis), and the development of inflammatory nodular lesions called granulomatosis [2]. We report a case with a 9-year-old girl presenting with severe hypereosinophilia, ischemic stroke, right-sided hemiparesis and myocarditis treated with methylprednisolone, enoxaparin, rivaroxaban and carvedilol. The patient recovered successfully from myocarditis and stroke but manifested with right-sided orbital involvement as pre-and post-septal orbital cellulitis 10 months later with necrotizing granu-lomatous perivascular chronic infiltration with eosinophilic infiltration treated with methylprednisolone and subsequent mepolizumab with successful remission of orbital involvement, but severe exogenous Cushing’s syndrome and myocardial fibrosis. |
Description: | Copyright © 2023 A. Panina Aleksandra, Ligere Elīna, Aleksejeva Elīna, Davidsone Zane, Cebure Elizabete, Erdmane Irina. Published by Vilnius University Press. |
DOI: | 10.15388/Amed.2023.30.1.5 |
ISSN: | 1392-0138 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Eosinophilic_Granulomatosis_with.pdf | 2.46 MB | Adobe PDF | View/Open |
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