Eosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvement

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dc.contributor.authorPanina, Aleksandra
dc.contributor.authorLigere, Elīna
dc.contributor.authorAleksejeva, Elīna
dc.contributor.authorDavidsone, Zane
dc.contributor.authorCebure, Elizabete
dc.contributor.authorErdmane, Irina
dc.contributor.institutionDepartment of Paediatrics
dc.date.accessioned2023-11-30T16:40:01Z
dc.date.available2023-11-30T16:40:01Z
dc.date.issued2023-01-24
dc.descriptionCopyright © 2023 A. Panina Aleksandra, Ligere Elīna, Aleksejeva Elīna, Davidsone Zane, Cebure Elizabete, Erdmane Irina. Published by Vilnius University Press.
dc.description.abstractHypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by peripheral blood eosinophilia of 1.5 × 109/L (1,500/μL) or greater, with evidence of end-organ damage attributable to eosinophilia (e.g., heart, liver or lung) with no other cause for the end-organ damage [1]. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disorder that may affect multiple organ systems (lungs, heart, kidneys, or the nervous system). The disorder is characterized by hypereosinophilia in the blood and tis-sues, inflammation of blood vessels (vasculitis), and the development of inflammatory nodular lesions called granulomatosis [2]. We report a case with a 9-year-old girl presenting with severe hypereosinophilia, ischemic stroke, right-sided hemiparesis and myocarditis treated with methylprednisolone, enoxaparin, rivaroxaban and carvedilol. The patient recovered successfully from myocarditis and stroke but manifested with right-sided orbital involvement as pre-and post-septal orbital cellulitis 10 months later with necrotizing granu-lomatous perivascular chronic infiltration with eosinophilic infiltration treated with methylprednisolone and subsequent mepolizumab with successful remission of orbital involvement, but severe exogenous Cushing’s syndrome and myocardial fibrosis.en
dc.description.statusPeer reviewed
dc.format.extent8
dc.format.extent2517341
dc.identifier.citationPanina, A, Ligere, E, Aleksejeva, E, Davidsone, Z, Cebure, E & Erdmane, I 2023, 'Eosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvement', Acta medica Lituanica, vol. 30, no. 1, pp. 45-52. https://doi.org/10.15388/Amed.2023.30.1.5
dc.identifier.doi10.15388/Amed.2023.30.1.5
dc.identifier.issn1392-0138
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15018
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85164140016&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofActa medica Lituanica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChurg–Strauss syn-drome
dc.subjecteosinophilic myocarditis
dc.subjectorbital involvement
dc.subjectpaediatric hypereosinophilic syndrome
dc.subjectstroke
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleEosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvementen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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