Please use this identifier to cite or link to this item:
10.3390/medicina59091577
Title: | Genotype Distribution and Characteristics of Chronic Hepatitis C Infection in Estonia, Latvia, Lithuania, and Ukraine : The RESPOND-C Study |
Authors: | Jančorienė, Ligita Rozentāle, Baiba Tolmane, Ieva Jēruma, Agita Salupere, Riina Buivydienė, Arida Valantinas, Jonas Kupčinskas, Limas Šumskienė, Jolanta Čiupkevičienė, Eglė Ambrozaitis, Arvydas Golubovska, Olga Moroz, Larysa Flisiak, Robert Bondar, Borys Faculty of Medicine |
Keywords: | Baltic states;chronic hepatitis C;fibrosis stage;genotype;routes of infection;Ukraine;3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine;SDG 3 - Good Health and Well-being |
Issue Date: | Sep-2023 |
Citation: | Jančorienė , L , Rozentāle , B , Tolmane , I , Jēruma , A , Salupere , R , Buivydienė , A , Valantinas , J , Kupčinskas , L , Šumskienė , J , Čiupkevičienė , E , Ambrozaitis , A , Golubovska , O , Moroz , L , Flisiak , R & Bondar , B 2023 , ' Genotype Distribution and Characteristics of Chronic Hepatitis C Infection in Estonia, Latvia, Lithuania, and Ukraine : The RESPOND-C Study ' , Medicina (Lithuania) , vol. 59 , no. 9 , 1577 . https://doi.org/10.3390/medicina59091577 |
Abstract: | Background and objectives: Since 2013, highly effective direct-acting antiviral (DAA) treatment for chronic hepatitis C (CHC) has become available, with cure rates exceeding 95%. For the choice of optimal CHC treatment, an assessment of the hepatitis C virus (HCV) genotype (GT) and liver fibrosis stage is necessary. Information about the distribution of these parameters among CHC patients in Estonia, Latvia, and Lithuania (the Baltic states) and especially in Ukraine is scarce. This study was performed to obtain epidemiologic data regarding CHC GT and fibrosis stage distribution for better planning of resources and prioritization of patients for DAA drug treatment according to disease severity in high-income (the Baltic states) and lower-middle-income (Ukraine) countries. Materials and methods: The retrospective RESPOND-C study included 1451 CHC patients. Demographic and disease information was collected from medical charts for each patient. Results: The most common suspected mode of viral transmission was blood transfusions (17.8%), followed by intravenous substance use (15.7%); however, in 50.9% of patients, the exact mode of transmission was not clarified. In Ukraine (18.4%) and Estonia (26%), transmission by intravenous substance use was higher than in Lithuania (5%) and Latvia (5.3%). Distribution of HCV GT among patients with CHC was as follows: GT1—66.4%; GT3—28.1; and GT2—4.1%. The prevalence of GT1 was the highest in Latvia (84%) and the lowest in Ukraine (63%, p < 0.001). Liver fibrosis stages were distributed as follows: F0—12.2%, F1—26.3%, F2—23.5%, F3—17.1%, and F4—20.9%. Cirrhosis (F4) was more prevalent in Lithuanian patients (30.1%) than in Estonians (8.1%, p < 0.001). Conclusions: This study contributes to the knowledge of epidemiologic characteristics of HCV infection in the Baltic states and Ukraine. The data regarding the patterns of HCV GT and fibrosis stage distribution will be helpful for the development of national strategies to control HCV infection in the era of DAA therapy. |
Description: | Publisher Copyright: © 2023 by the authors. |
DOI: | 10.3390/medicina59091577 |
ISSN: | 1010-660X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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