Please use this identifier to cite or link to this item:
10.3389/fphys.2023.1180288
Title: | Contactless photoplethysmography for assessment of small fiber neuropathy |
Authors: | Marcinkevics, Zbignevs Rubins, Uldis Aglinska, Alise Logina, Inara Glazunovs, Dmitrijs Grabovskis, Andris Department of Neurology and Neurosurgery |
Keywords: | Axon reflex flare;Cutaneous vasomotion;Imaging photoplethysmography;Optical diagnostic imaging;Remote photoplethysmography;Small fiber neuropathy;Topical heating;Vasomotor responses;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | 23-Aug-2023 |
Citation: | Marcinkevics , Z , Rubins , U , Aglinska , A , Logina , I , Glazunovs , D & Grabovskis , A 2023 , ' Contactless photoplethysmography for assessment of small fiber neuropathy ' , Frontiers in Physiology , vol. 14 , 1180288 , pp. 01 -16 . https://doi.org/10.3389/fphys.2023.1180288 |
Abstract: | Chronic pain is a prevalent condition affecting approximately one-fifth of the global population, with significant impacts on quality of life and work productivity. Small fiber neuropathies are a common cause of chronic pain, and current diagnostic methods rely on subjective self-assessment or invasive skin biopsies, highlighting the need for objective noninvasive assessment methods. The study aims to develop a modular prototype of a contactless photoplethysmography system with three spectral bands (420, 540, and 800 nm) and evaluate its potential for assessing peripheral neuropathy patients via a skin topical heating test and spectral analyses of cutaneous flowmotions. The foot topical skin heating test was conducted on thirty volunteers, including fifteen healthy subjects and fifteen neuropathic patients. Four cutaneous nerve fiber characterizing parameters were evaluated at different wavelengths, including vasomotor response trend, flare area, flare intensity index, and the spectral power of cutaneous flowmotions. The results show that neuropathic patients had significantly lower vasomotor response (50%), flare area (63%), flare intensity index (19%), and neurogenic component (54%) of cutaneous flowmotions compared to the control group, independent of photoplethysmography spectral band. An absolute value of perfusion was 20%–30% higher in the 420 nm band. Imaging photoplethysmography shows potential as a cost-effective alternative for objective and non-invasive assessment of neuropathic patients, but further research is needed to enhance photoplethysmography signal quality and establish diagnostic criteria. |
Description: | Publisher Copyright: Copyright © 2023 Marcinkevics, Rubins, Aglinska, Logina, Glazunovs and Grabovskis. |
DOI: | 10.3389/fphys.2023.1180288 |
ISSN: | 1664-042X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Contactless_photoplethysmography_for_assessment.pdf | 2.99 MB | Adobe PDF | View/Open |
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