Please use this identifier to cite or link to this item:
10.3390/biomimetics8050409
Title: | Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applications |
Authors: | Kimia, Alizadeh Dezvare, Yasaman Kamyab, Shirin Amirian , Jhaleh Brangule, Agnese Bandere, Dace Department of Pharmaceutical Chemistry |
Keywords: | carrageenan (CRG);cerium oxide (CeO2);;nanoparticles (NPs);composite;Antibacterial properties;hemostatic effect;1.6 Biological sciences;2.10 Nano-technology;2.5 Materials engineering;2.11 Other engineering and technologies;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | 4-Sep-2023 |
Citation: | Kimia , A , Dezvare , Y , Kamyab , S , Amirian , J , Brangule , A & Bandere , D 2023 , ' Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applications ' , Biomimetics , vol. 8 , no. 5 , 409 . https://doi.org/10.3390/biomimetics8050409 |
Abstract: | In this study, a novel absorbable hemostatic agent was developed using carrageenan (CRG) as a natural polymer and cerium oxide nanoparticles (CeO2 NPs). CRG-CeO2-0.5 and CRG-CeO2-1 composites were prepared by compositing CeO2 to CRG + CeO2 at a weight ratio of 0.5:100 and 1:100, respectively. The physicochemical and structural properties of these compounds were studied and compared with pristine CRG. Upon incorporation of CeO2 nanoparticles into the CRG matrix, significant reductions in hydrogel degradation were observed. In addition, it was noted that CRG-CeO2 exhibited better antibacterial and hemostatic properties than CRG hydrogel without CeO2 NPs. The biocompatibility of the materials was tested using the NIH 3T3 cell line, and all samples were found to be nontoxic. Particularly, CRG-CeO2-1 demonstrated superior hemostatic effects, biocompatibility, and a lower degradation rate since more CeO2 NPs were present in the CRG matrix. Therefore, CRG-CeO2-1 has the potential to be used as a hemostatic agent and wound dressing. |
Description: | Funding Information: Authors acknowledge funding from the European Union’s Horizon 2020 research and innovation programme under the Grant Agreement No. 857287 (BBCE). Publisher Copyright: © 2023 by the authors. |
DOI: | 10.3390/biomimetics8050409 |
ISSN: | 2313-7673 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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biomimetics-08-00409.pdf | 11.02 MB | Adobe PDF | View/Open |
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