Please use this identifier to cite or link to this item:
10.1038/s41366-023-01344-y
Title: | Distinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgery |
Authors: | Šlisere, B. Arisova, M. Aizbalte, O. Salmiņa, M. M. Zolovs, M. Levenšteins, M. Mukāns, M. Troickis, I. Meija, L. Lejnieks, A. Bīlande, G. Rosser, E. C. Oļeiņika, K. Department of Doctoral Studies Department of Human Physiology and Biochemistry Institute of Public Health Statistics Unit Department of Internal Diseases |
Keywords: | 3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Medicine (miscellaneous);Endocrinology, Diabetes and Metabolism;Nutrition and Dietetics;SDG 3 - Good Health and Well-being |
Issue Date: | Oct-2023 |
Citation: | Šlisere , B , Arisova , M , Aizbalte , O , Salmiņa , M M , Zolovs , M , Levenšteins , M , Mukāns , M , Troickis , I , Meija , L , Lejnieks , A , Bīlande , G , Rosser , E C & Oļeiņika , K 2023 , ' Distinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgery ' , International Journal of Obesity , vol. 47 , no. 10 , pp. 970-978 . https://doi.org/10.1038/s41366-023-01344-y |
Abstract: | BACKGROUND/OBJECTIVES: Obesity-associated metabolic dysfunction and inflammation can be ameliorated by bariatric surgery. While obesity is also linked to impaired B cell activation, differentiation, and persistence in response to infection and vaccination little is known about post-operative immune B cell compartment and to what extent dysregulation in B cell pathways can be reversed. To bridge this gap in knowledge, we carried out in-depth evaluation of B cell composition in individuals with obesity prior to and following bariatric surgery compared to lean controls. SUBJECTS/METHODS: We recruited individuals with obesity (BMI at least 35 kg/m 2) before bariatric surgery (n = 21) and followed them up 6 months post-operatively (n = 17). As controls we recruited age- and sex-matched lean (BMI < 25) individuals (n = 18). We carried out comprehensive immunophenotyping of peripheral blood B cells as well as interrogated their association with inflammatory and metabolic parameters. RESULTS: In obesity the balance of antigen-inexperienced and memory B cells in the peripheral blood is altered, with an expansion of naïve and a reduction in total memory B cells. 6 months following bariatric surgery this balance is restored. However, post-operative patients are uniquely characterised by an increase in B cell subsets associated with chronic inflammation - CD11c +CXCR5 -IgD -CD27 - double negative 2 (DN2) B cells and CD27 +CD38 ++ plasmablasts. Correlations between B cells subsets, inflammatory and metabolic parameters were distinct in lean people and individuals with obesity pre- and post-bariatric surgery. CONCLUSIONS: Bariatric surgery patients display a unique B cell profile 6 months post-operatively; this bears minimal resemblance to that of pre-operative patients and only partially overlaps with that of lean controls. Post-operative differences in the B cell compartment compared to lean controls are detected despite global amelioration of inflammation and restoration of metabolic health. Collectively, this indicates that bariatric surgery creates a specific immunometabolic state with potential implications for health outcomes. |
Description: | Funding Information: KO is supported by a Latvian Council of Science Grant Nr. lzp-2020/2-0222 awarded to KO and Nr. lzp-2019/1-0139 awarded to Harijs Čerņevskis. EC Rosser is supported by a Medical Research Foundation Fellowship (MRF-057-0001-RG-ROSS-C0797) and a Senior Research Fellowship from the Kennedy Trust for Rheumatology Research (KENN 21 22 09). Funding Information: KO is supported by a Latvian Council of Science Grant Nr. lzp-2020/2-0222 awarded to KO and Nr. lzp-2019/1-0139 awarded to Harijs Čerņevskis. EC Rosser is supported by a Medical Research Foundation Fellowship (MRF-057-0001-RG-ROSS-C0797) and a Senior Research Fellowship from the Kennedy Trust for Rheumatology Research (KENN 21 22 09). Publisher Copyright: © 2023, The Author(s). |
DOI: | 10.1038/s41366-023-01344-y |
ISSN: | 0307-0565 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Distinct_B_cell_profiles_characterise.pdf | 2.04 MB | Adobe PDF | View/Open |
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