Distinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgery

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dc.contributor.authorŠlisere, B.
dc.contributor.authorArisova, M.
dc.contributor.authorAizbalte, O.
dc.contributor.authorSalmiņa, M. M.
dc.contributor.authorZolovs, M.
dc.contributor.authorLevenšteins, M.
dc.contributor.authorMukāns, M.
dc.contributor.authorTroickis, I.
dc.contributor.authorMeija, L.
dc.contributor.authorLejnieks, A.
dc.contributor.authorBīlande, G.
dc.contributor.authorRosser, E. C.
dc.contributor.authorOļeiņika, K.
dc.contributor.institutionDepartment of Doctoral Studies
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.contributor.institutionInstitute of Public Health
dc.contributor.institutionStatistics Unit
dc.contributor.institutionDepartment of Internal Diseases
dc.date.accessioned2023-07-31T09:05:01Z
dc.date.available2023-07-31T09:05:01Z
dc.date.issued2023-10
dc.descriptionFunding Information: KO is supported by a Latvian Council of Science Grant Nr. lzp-2020/2-0222 awarded to KO and Nr. lzp-2019/1-0139 awarded to Harijs Čerņevskis. EC Rosser is supported by a Medical Research Foundation Fellowship (MRF-057-0001-RG-ROSS-C0797) and a Senior Research Fellowship from the Kennedy Trust for Rheumatology Research (KENN 21 22 09). Funding Information: KO is supported by a Latvian Council of Science Grant Nr. lzp-2020/2-0222 awarded to KO and Nr. lzp-2019/1-0139 awarded to Harijs Čerņevskis. EC Rosser is supported by a Medical Research Foundation Fellowship (MRF-057-0001-RG-ROSS-C0797) and a Senior Research Fellowship from the Kennedy Trust for Rheumatology Research (KENN 21 22 09). Publisher Copyright: © 2023, The Author(s).
dc.description.abstractBACKGROUND/OBJECTIVES: Obesity-associated metabolic dysfunction and inflammation can be ameliorated by bariatric surgery. While obesity is also linked to impaired B cell activation, differentiation, and persistence in response to infection and vaccination little is known about post-operative immune B cell compartment and to what extent dysregulation in B cell pathways can be reversed. To bridge this gap in knowledge, we carried out in-depth evaluation of B cell composition in individuals with obesity prior to and following bariatric surgery compared to lean controls. SUBJECTS/METHODS: We recruited individuals with obesity (BMI at least 35 kg/m 2) before bariatric surgery (n = 21) and followed them up 6 months post-operatively (n = 17). As controls we recruited age- and sex-matched lean (BMI < 25) individuals (n = 18). We carried out comprehensive immunophenotyping of peripheral blood B cells as well as interrogated their association with inflammatory and metabolic parameters. RESULTS: In obesity the balance of antigen-inexperienced and memory B cells in the peripheral blood is altered, with an expansion of naïve and a reduction in total memory B cells. 6 months following bariatric surgery this balance is restored. However, post-operative patients are uniquely characterised by an increase in B cell subsets associated with chronic inflammation - CD11c +CXCR5 -IgD -CD27 - double negative 2 (DN2) B cells and CD27 +CD38 ++ plasmablasts. Correlations between B cells subsets, inflammatory and metabolic parameters were distinct in lean people and individuals with obesity pre- and post-bariatric surgery. CONCLUSIONS: Bariatric surgery patients display a unique B cell profile 6 months post-operatively; this bears minimal resemblance to that of pre-operative patients and only partially overlaps with that of lean controls. Post-operative differences in the B cell compartment compared to lean controls are detected despite global amelioration of inflammation and restoration of metabolic health. Collectively, this indicates that bariatric surgery creates a specific immunometabolic state with potential implications for health outcomes.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.format.extent2086953
dc.identifier.citationŠlisere, B, Arisova, M, Aizbalte, O, Salmiņa, M M, Zolovs, M, Levenšteins, M, Mukāns, M, Troickis, I, Meija, L, Lejnieks, A, Bīlande, G, Rosser, E C & Oļeiņika, K 2023, 'Distinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgery', International Journal of Obesity, vol. 47, no. 10, pp. 970-978. https://doi.org/10.1038/s41366-023-01344-y
dc.identifier.doi10.1038/s41366-023-01344-y
dc.identifier.issn0307-0565
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14182
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85165075823&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Obesity
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectMedicine (miscellaneous)
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectNutrition and Dietetics
dc.subjectSDG 3 - Good Health and Well-being
dc.titleDistinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgeryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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