Please use this identifier to cite or link to this item:
10.1111/bjh.18685
Title: | Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia |
Authors: | Karlsson, Lene Cheuk, Daniel De Moerloose, Barbara Hasle, Henrik Jahnukainen, Kirsi Juul-Dam, Kristian Løvvik Kaspers, Gertjan Kovalova, Zanna Lausen, Birgitte Nyström, Ulrika Norén Palle, Josefine Pronk, Cornelis Jan Saks, Kadri Tierens, Anne Zeller, Bernward Abrahamsson, Jonas |
Keywords: | acute myeloid leukaemia;paediatric;resistant disease;survival;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Hematology |
Issue Date: | May-2023 |
Citation: | Karlsson , L , Cheuk , D , De Moerloose , B , Hasle , H , Jahnukainen , K , Juul-Dam , K L , Kaspers , G , Kovalova , Z , Lausen , B , Nyström , U N , Palle , J , Pronk , C J , Saks , K , Tierens , A , Zeller , B & Abrahamsson , J 2023 , ' Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia ' , British Journal of Haematology , vol. 201 , no. 4 , pp. 757-765 . https://doi.org/10.1111/bjh.18685 |
Abstract: | A significant proportion of events in paediatric acute myeloid leukaemia (AML) are caused by resistant disease (RD). We investigated clinical and biological characteristics in 66 patients with RD from 1013 children with AML registered and treated according to the NOPHO-AML 93, NOPHO-AML 2004, DB AML-01 and NOPHO-DBH AML 2012 protocols. Risk factors for RD were age10 years or older and a white-blood-cell count (WBC) of 100 × 109/L or more at diagnosis. The five-year overall survival (OS) was 38% (95% confidence interval [CI]: 28%–52%). Of the 63 children that received salvage therapy with chemotherapy, 59% (N = 37) achieved complete remission (CR) with OS 57% (95% CI: 42%–75%) compared to 12% (95% CI: 4%–35%) for children that did not achieve CR. Giving more than two salvage chemotherapy courses did not increase CR rates. OS for all 43 patients receiving allogeneic haematopoietic stem cell transplantation (HSCT) was 49% (95% CI: 36%–66%). Those achieving CR and proceeding to HSCT had an OS of 56% (95% CI: 41%–77%, N = 30). This study showed that almost 40% of children with primary resistant AML can be cured with salvage therapy followed by HSCT. Children that did not achieve CR after two salvage courses with chemotherapy did not benefit from additional chemotherapy. |
Description: | Funding Information: The study was financed by grants from the Swedish Childrens´ Cancer foundation and the Swedish state under the agreement between the Swedish government and the county councils, the ALF‐agreement (ALFGBG‐966256). Publisher Copyright: © 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. |
DOI: | 10.1111/bjh.18685 |
ISSN: | 0007-1048 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Characteristics_and_outcome_of_primary.pdf | 773.08 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.