Please use this identifier to cite or link to this item:
10.3390/medicina59040798
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lukjanoviča, Kristīne | - |
dc.contributor.author | Šlēziņa, Ieva | - |
dc.contributor.author | Dāvidsone, Zane | - |
dc.contributor.author | Šantere, Ruta | - |
dc.contributor.author | Budarina, Kristīna | - |
dc.contributor.author | Staņēviča, Valda | - |
dc.date.accessioned | 2023-05-03T08:50:01Z | - |
dc.date.available | 2023-05-03T08:50:01Z | - |
dc.date.issued | 2023-04-20 | - |
dc.identifier.citation | Lukjanoviča , K , Šlēziņa , I , Dāvidsone , Z , Šantere , R , Budarina , K & Staņēviča , V 2023 , ' Systemic Juvenile Idiopathic Arthritis and Secondary Macrophage Activation Syndrome in Latvia from 2009 to 2020 : A Nationwide Retrospective Study ' , Medicina (Kaunas, Lithuania) , vol. 59 , no. 4 , 798 . https://doi.org/10.3390/medicina59040798 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.other | PubMedCentral: PMC10144400 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/11864 | - |
dc.description | Zane Davidsone is a representative of European Reference Network on Connective Tissue and Musculoskeletal Disease-ERN-ReCONNET. | - |
dc.description.abstract | Background and Objectives: Systemic juvenile idiopathic arthritis (sJIA) is a distinctive JIA subtype with mostly nonspecific systemic clinical features, which can be a diagnostic challenge. This study aimed to analyze our experience with sJIA in Latvia for twelve years: assessing clinical and epidemiological characteristics, the efficacy of therapy, and disease outcomes, including the development of macrophage activation syndrome (MAS). Materials and methods: This is a descriptive study in which we conducted a retrospective case review of all patients with sJIA diagnosis admitted to the only pediatric tertiary centre in Latvia during the period 2009-2020. Results: sJIA was diagnosed in 35 patients with a mean annual incidence rate of 0.85 patients per 100,000 children. Major clinical signs at the first visit were: fever, rash, arthritis, and lymphadenopathy. Almost half of the patients, 48.5%, had a monocyclic disease course, and only 20% of patients had persistent disease. MAS developed in 28.6% of patients. Biological therapy was administered to 48.6% of patients, mostly by tocilizumab, which induced remission in 75% after one year, and in 81.2% after two years without any serious therapy-related complications. In our study, none of the patients had interstitial lung disease, drug reaction with eosinophilia and systemic symptoms (DRESS)-like syndrome, or fatal disease. Conclusions: The incidence and clinical characteristics of sJIA correlate with the literature findings, although MAS was more common than described in other studies. There is a tendency for the persistent disease to decrease with the use of biological therapy. Tocilizumab is an efficient choice of treatment with a good safety profile. | en |
dc.format.extent | 309191 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Medicina (Kaunas, Lithuania) | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | juvenile arthritis | - |
dc.subject | systemic juvenile idiopathic arthritis | - |
dc.subject | sJIA | - |
dc.subject | still’s disease | - |
dc.subject | macrophage activation syndrome; | - |
dc.subject | MAS | - |
dc.subject | tocilizumab | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.title | Systemic Juvenile Idiopathic Arthritis and Secondary Macrophage Activation Syndrome in Latvia from 2009 to 2020 : A Nationwide Retrospective Study | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/medicina59040798 | - |
dc.contributor.institution | Residency Unit | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.contributor.institution | Department of Paediatrics | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85156178116&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Systemic_Juvenile_Idiopathic_Arthritis.pdf | 301.94 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.