Please use this identifier to cite or link to this item:
10.1093/cei/uxac079
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Oleinika, Kristine | - |
dc.contributor.author | Slisere, Baiba | - |
dc.contributor.author | Catalán, Diego | - |
dc.contributor.author | Rosser, Elizabeth C. | - |
dc.date.accessioned | 2023-04-19T11:15:01Z | - |
dc.date.available | 2023-04-19T11:15:01Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.citation | Oleinika , K , Slisere , B , Catalán , D & Rosser , E C 2022 , ' B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity ' , Clinical and Experimental Immunology , vol. 210 , no. 3 , pp. 263-272 . https://doi.org/10.1093/cei/uxac079 | - |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/11716 | - |
dc.description.abstract | Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens. | en |
dc.format.extent | 1473728 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Clinical and Experimental Immunology | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview | - |
dc.identifier.doi | 10.1093/cei/uxac079 | - |
dc.contributor.institution | Department of Internal Diseases | - |
dc.contributor.institution | Department of Doctoral Studies | - |
dc.identifier.url | https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:000846912200001 | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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B_cell_contribution_to_immunometabolic_dysfunction.pdf | 1.44 MB | Adobe PDF | View/Open |
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