Please use this identifier to cite or link to this item:
10.1093/cei/uxac079
Title: | B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity |
Authors: | Oleinika, Kristine Slisere, Baiba Catalán, Diego Rosser, Elizabeth C. Department of Internal Diseases Department of Doctoral Studies |
Keywords: | 3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;SDG 3 - Good Health and Well-being |
Issue Date: | Dec-2022 |
Citation: | Oleinika , K , Slisere , B , Catalán , D & Rosser , E C 2022 , ' B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity ' , Clinical and Experimental Immunology , vol. 210 , no. 3 , pp. 263-272 . https://doi.org/10.1093/cei/uxac079 |
Abstract: | Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens. |
DOI: | 10.1093/cei/uxac079 |
ISSN: | 0009-9104 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
B_cell_contribution_to_immunometabolic_dysfunction.pdf | 1.44 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.