B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity

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dc.contributor.authorOleinika, Kristine
dc.contributor.authorSlisere, Baiba
dc.contributor.authorCatalán, Diego
dc.contributor.authorRosser, Elizabeth C.
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionDepartment of Doctoral Studies
dc.date.accessioned2023-04-19T11:15:01Z
dc.date.available2023-04-19T11:15:01Z
dc.date.issued2022-12
dc.description.abstractObesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens.en
dc.description.statusPeer reviewed
dc.format.extent1473728
dc.identifier.citationOleinika, K, Slisere, B, Catalán, D & Rosser, E C 2022, 'B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity', Clinical and Experimental Immunology, vol. 210, no. 3, pp. 263-272. https://doi.org/10.1093/cei/uxac079
dc.identifier.doi10.1093/cei/uxac079
dc.identifier.issn0009-9104
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/11716
dc.identifier.urlhttps://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:000846912200001
dc.language.isoeng
dc.relation.ispartofClinical and Experimental Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleB cell contribution to immunometabolic dysfunction and impaired immune responses in obesityen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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