Please use this identifier to cite or link to this item:
10.2478/prolas-2022-0033
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Mitiļdžans, Androniks | - |
dc.contributor.author | Zablocka, Tatjana | - |
dc.contributor.author | Isajevs, Sergejs | - |
dc.contributor.author | Gordjušina, Valentina | - |
dc.contributor.author | Rezeberga, Dace | - |
dc.date.accessioned | 2023-01-31T10:45:01Z | - |
dc.date.available | 2023-01-31T10:45:01Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.citation | Mitiļdžans , A , Zablocka , T , Isajevs , S , Gordjušina , V & Rezeberga , D 2022 , ' Upregulation of FOXP3+Regulatory T Lymphocytes and CD8+Lymphocytes in Patients with High-Grade Squamous Intraepithelial Lesions Correlated with HPV Infection ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 76 , no. 2 , pp. 218-224 . https://doi.org/10.2478/prolas-2022-0033 | - |
dc.identifier.issn | 1407-009X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/10218 | - |
dc.description | Raksts ir publicēts 2022.gada aprīlī. Tas redzams žurnāla publikācijā, raksta PDF publikācijā un Web of Science publikācijā. Scopus datubāzē publicēšanas gads ir norādīts kļūdaini kā 2021.gads. Publisher Copyright: © Latvian Academy of Sciences. | - |
dc.description.abstract | Modern therapeutic strategies for precancerous cervical intraepithelial neoplasia (CIN) focus on immune-modulatory and cancer vaccination. The local cervical immune status in cervical cancer and CIN could influence HPV infection persistence, progression and carcinogenesis. We analysed the role of FOXP3+ regulatory T lymphocytes, CD4+ and CD8+ T lymphocytes in CIN I, CIN II and CIN III patients with and without HPV infection. Sixty-two patients were enrolled in the study. Each patient underwent a colposcopy-guided cervical biopsy. FOXP3+ lymphocytes and CD4+,CD8+ lymphocytes were detected by immunostaining in tissue samples obtained from a control group (n = 10), patients with CIN I (n = 20), CIN II (n = 14) and CIN III (n = 18) lesions. HPV was assayed by Aptima. The results showed that the numbers of CD4+ T lymphocytes did not differ between patients with CIN I, CIN II, and CIN III. However, patients with CIN II and CIN III had significantly upregulated CD8+T lymphocytes compared to patients with CIN I. In addition, patients with CIN II and CIN III had increased FOXP3 + T lymphocytes compared with patients with CIN I, which was associated with HPV status. Upregulation of FOXP3+ regulatory T lymphocytes and CD8-positive lymphocytes in patients with CIN II and CIN III suggested a pivotal role of T regulatory lymphocytes and CD8+ lymphocytes for counteracting the host immune response in the progression from CIN I to CIN II and CIN III. | en |
dc.format.extent | 7 | - |
dc.format.extent | 1070018 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | cervical intraepithelial neoplasia (CIN) | - |
dc.subject | HPV (human papilloma virus) | - |
dc.subject | lymphocytes | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Upregulation of FOXP3+Regulatory T Lymphocytes and CD8+Lymphocytes in Patients with High-Grade Squamous Intraepithelial Lesions Correlated with HPV Infection | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.2478/prolas-2022-0033 | - |
dc.contributor.institution | Department of Obstetrics and Gynaecology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85142324995&partnerID=8YFLogxK | - |
dc.identifier.url | https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/BCI:BCI202200533912 | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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UPREGULATION_OF_FOXP3_REGULATORY_T_LYMPHOCYTES.pdf | 1.04 MB | Adobe PDF | View/Open |
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