Please use this identifier to cite or link to this item:
10.3390/nu14091889
Title: | Chronic Intestinal Failure in Children : An International Multicenter Cross-Sectional Survey |
Authors: | Lezo, Antonella Diamanti, Antonella Marinier, Evelyne M. Tabbers, Merit Guz-Mark, Anat Gandullia, Paolo Spagnuolo, Maria I. Protheroe, Sue Peretti, Noel Merras-Salmio, Laura Hulst, Jessie M. Kolaček, Sanja Ee, Looi C. Lawrence, Joanna Hind, Jonathan D’antiga, Lorenzo Verlato, Giovanna Pukite, Ieva Di Leo, Grazia Vanuytsel, Tim Doitchinova-Simeonova, Maryana K. Ellegard, Lars Masconale, Luisa Maíz-Jiménez, María Cooper, Sheldon C. Brillanti, Giorgia Nardi, Elena Sasdelli, Anna S. Lal, Simon Pironi, Loris |
Keywords: | body growth;children;chronic intestinal failure;home parenteral nutrition;intestinal transplantation;intravenous supplementation;transition;3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Food Science;Nutrition and Dietetics |
Issue Date: | 1-May-2022 |
Citation: | Lezo , A , Diamanti , A , Marinier , E M , Tabbers , M , Guz-Mark , A , Gandullia , P , Spagnuolo , M I , Protheroe , S , Peretti , N , Merras-Salmio , L , Hulst , J M , Kolaček , S , Ee , L C , Lawrence , J , Hind , J , D’antiga , L , Verlato , G , Pukite , I , Di Leo , G , Vanuytsel , T , Doitchinova-Simeonova , M K , Ellegard , L , Masconale , L , Maíz-Jiménez , M , Cooper , S C , Brillanti , G , Nardi , E , Sasdelli , A S , Lal , S & Pironi , L 2022 , ' Chronic Intestinal Failure in Children : An International Multicenter Cross-Sectional Survey ' , Nutrients , vol. 14 , no. 9 , 1889 . https://doi.org/10.3390/nu14091889 |
Abstract: | Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1–4 and 14–18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children. |
Description: | Funding Information: Funding: The project of the ESPEN database for Chronic Intestinal Failure was promoted by the ESPEN Executive Committee in 2013, was approved by the ESPEN Council and was supported by an ESPEN grant. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
DOI: | 10.3390/nu14091889 |
ISSN: | 2072-6643 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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File | Size | Format | |
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Chronic_Intestinal_Failure_in_Children.pdf | 1.09 MB | Adobe PDF | View/Open |
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