Please use this identifier to cite or link to this item: 10.2478/prolas-2020-0023
Title: T-Cell lymphoma misdiagnosed as Crohn's disease : Case report
Authors: Straume, Zane
Māliņa, Justīne
Proskurina, Anna
Nazarovs, Jurijs
Derovs, Aleksejs
Dubois, Patrick
Rīga Stradiņš University
Keywords: Crohn's disease;Inflammatory bowel diseases;PTCL-NOS;T-cell lymphoma;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General;SDG 3 - Good Health and Well-being
Issue Date: 2020
Citation: Straume , Z , Māliņa , J , Proskurina , A , Nazarovs , J , Derovs , A & Dubois , P 2020 , ' T-Cell lymphoma misdiagnosed as Crohn's disease : Case report ' , Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. , vol. 74 , no. 2 , pp. 144-149 . https://doi.org/10.2478/prolas-2020-0023
Abstract: For many years, there has been a concern that inflammatory bowel disease carries an increased lymphoma risk. At the same time, patients with intestinal lymphomas are occasionally misdiagnosed as having Crohn's disease. We report a case of T-cell lymphoma of the bowel misdiagnosed as Crohn's disease, which illustrates the diagnostic challenges posed by peripheral extranodal lymphomas. A 68-year old female presented with clinical symptoms (diarrhoea, abdominal pain, poor appetite and significant weight loss), and colonoscopic and initial histological findings that were similar to inflammatory bowel disease. She was diagnosed with Crohn's disease and received treatment with sulfasalazine with subsequent improvement of symptoms. Eight months after the initial diagnosis the patient experienced sudden abdominal pain. Laparotomy revealed necrosis in the small and large intestine and ileostomy was performed. On day 10 of a complicated postoperative period the patient died. Post-mortem histopathological examination of small and large intestine revealed highly malignant peripheral T-cell lymphoma, not otherwise specified. Differentiation of intestinal T-cell lymphoma from Crohn's disease continues to be a challenge, because clinical, colonoscopic, radiological and histopathological findings can mimic Crohn's disease. Careful multi-disciplinary assessment and knowledge of this rare disorder is crucial for timely diagnosis.
Description: Funding Information: This paper was published with the support of the non-profit organisation, Digestive Disease Society. Publisher Copyright: © 2020 Sciendo. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
DOI: 10.2478/prolas-2020-0023
ISSN: 1407-009X
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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