T-Cell lymphoma misdiagnosed as Crohn's disease : Case report

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dc.contributor.authorStraume, Zane
dc.contributor.authorMāliņa, Justīne
dc.contributor.authorProskurina, Anna
dc.contributor.authorNazarovs, Jurijs
dc.contributor.authorDerovs, Aleksejs
dc.contributor.authorDubois, Patrick
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2023-01-16T13:40:02Z
dc.date.available2023-01-16T13:40:02Z
dc.date.issued2020
dc.descriptionFunding Information: This paper was published with the support of the non-profit organisation, Digestive Disease Society. Publisher Copyright: © 2020 Sciendo. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractFor many years, there has been a concern that inflammatory bowel disease carries an increased lymphoma risk. At the same time, patients with intestinal lymphomas are occasionally misdiagnosed as having Crohn's disease. We report a case of T-cell lymphoma of the bowel misdiagnosed as Crohn's disease, which illustrates the diagnostic challenges posed by peripheral extranodal lymphomas. A 68-year old female presented with clinical symptoms (diarrhoea, abdominal pain, poor appetite and significant weight loss), and colonoscopic and initial histological findings that were similar to inflammatory bowel disease. She was diagnosed with Crohn's disease and received treatment with sulfasalazine with subsequent improvement of symptoms. Eight months after the initial diagnosis the patient experienced sudden abdominal pain. Laparotomy revealed necrosis in the small and large intestine and ileostomy was performed. On day 10 of a complicated postoperative period the patient died. Post-mortem histopathological examination of small and large intestine revealed highly malignant peripheral T-cell lymphoma, not otherwise specified. Differentiation of intestinal T-cell lymphoma from Crohn's disease continues to be a challenge, because clinical, colonoscopic, radiological and histopathological findings can mimic Crohn's disease. Careful multi-disciplinary assessment and knowledge of this rare disorder is crucial for timely diagnosis.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent10086307
dc.identifier.citationStraume, Z, Māliņa, J, Proskurina, A, Nazarovs, J, Derovs, A & Dubois, P 2020, 'T-Cell lymphoma misdiagnosed as Crohn's disease : Case report', Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., vol. 74, no. 2, pp. 144-149. https://doi.org/10.2478/prolas-2020-0023
dc.identifier.doi10.2478/prolas-2020-0023
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/10085
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85092935515&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCrohn's disease
dc.subjectInflammatory bowel diseases
dc.subjectPTCL-NOS
dc.subjectT-cell lymphoma
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.subjectSDG 3 - Good Health and Well-being
dc.titleT-Cell lymphoma misdiagnosed as Crohn's disease : Case reporten
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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