Please use this identifier to cite or link to this item:
10.1371/journal.pone.0275336
Title: | Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe : A cross-sectional survey of paediatricians |
Authors: | Dewez, Juan Emmanuel Pembrey, Lucy Nijman, Ruud G. del Torso, Stefano Grossman, Zachi Hadjipanayis, Adamos Van Esso, Diego Lim, Emma Emonts, Marieke Burns, James Gras-LeGuen, Christèle Kohlfuerst, Daniela Dornbusch, Hans Jürgen Brengel-Pesce, Karen Mallet, Francois von Both, Ulrich Tsolia, Maria Eleftheriou, Irini Zavadska, Dace de Groot, Ronald van der Flier, Michiel Moll, Henriëtte Hagedoorn, Nienke Borensztajn, Dorine Oostenbrink, Rianne Kuijpers, Taco Pokorn, Marko Vincek, Katarina Martinó n-Torres, Federico Rivero, Irene Agyeman, Philipp Carrol, Enitan D. Paulus, Stéphane Cunnington, Aubrey Herberg, Jethro Levin, Michael Mujkić, Aida Geitmann, Karin Da Dalt, Liviana Valiulis, Arunas Lapatto, Risto Syridou, Garyfallia Altorjai, Péter Torpiano, Paul Størdal, Ketil Illy, Károly Mazur, Artur Spreitzer, Mateja Vintar Rios, Joana Wyder, Corinne Romankevych, Ivanna Basmaci, Romain Ibanez-Mico, Salvador Yeung, Shunmay |
Keywords: | 3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;General |
Issue Date: | Dec-2022 |
Citation: | Dewez , J E , Pembrey , L , Nijman , R G , del Torso , S , Grossman , Z , Hadjipanayis , A , Van Esso , D , Lim , E , Emonts , M , Burns , J , Gras-LeGuen , C , Kohlfuerst , D , Dornbusch , H J , Brengel-Pesce , K , Mallet , F , von Both , U , Tsolia , M , Eleftheriou , I , Zavadska , D , de Groot , R , van der Flier , M , Moll , H , Hagedoorn , N , Borensztajn , D , Oostenbrink , R , Kuijpers , T , Pokorn , M , Vincek , K , Martinó n-Torres , F , Rivero , I , Agyeman , P , Carrol , E D , Paulus , S , Cunnington , A , Herberg , J , Levin , M , Mujkić , A , Geitmann , K , Da Dalt , L , Valiulis , A , Lapatto , R , Syridou , G , Altorjai , P , Torpiano , P , Størdal , K , Illy , K , Mazur , A , Spreitzer , M V , Rios , J , Wyder , C , Romankevych , I , Basmaci , R , Ibanez-Mico , S & Yeung , S 2022 , ' Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe : A cross-sectional survey of paediatricians ' , PloS one , vol. 17 , no. 12 , e0275336 . https://doi.org/10.1371/journal.pone.0275336 |
Abstract: | Background Point-of-care-tests (POCTs) have been advocated to optimise care in patients with infections but their actual use varies. This study aimed to estimate the variability in the adoption of current POCTs by paediatricians across Europe, and to explore the determinants of variability. Methods and findings A cross-sectional survey was conducted of hospital and primary care paediatricians, recruited through professional networks. Questions focused on the availability and use of currently available POCTs. Data were analysed descriptively and using Median Odds Ratio (MOR) to measure variation between countries. Multilevel regression modelling using changes in the area under the receiver operating characteristic curve of models were used to assess the contribution of individual or workplace versus country level factors, to the observed variation. The commonest POCT was urine dipsticks (UD) which were available to >80% of primary care and hospital paediatricians in 68% (13/19) and 79% (23/29) countries, respectively. Availability of all POCTs varied between countries. In primary care, the country (MOR) varied from 1.61 (95%CI: 1.04-2.58) for lactate to 7.28 (95%CI: 3.04-24.35) for UD. In hospitals, the country MOR varied from 1.37 (95%CI:1.04-1.80) for lactate to 11.93 (95% CI:3.35-72.23) for UD. Most paediatricians in primary care (69%, 795/1154) and hospital (81%, 962/1188) would use a diagnostic test in the case scenario of an infant with undifferentiated fever. Multilevel regression modelling showed that the country of work was more important in predicting both the availability and use of POCTs than individual or workplace characteristics. Conclusion There is substantial variability in the adoption of POCTs for the management of acute infections in children across Europe. To inform future implementation of both existing and innovative tests, further research is needed to understand what drives the variation between countries, the needs of frontline clinicians, and the role of diagnostic tests in the management of acute childhood infections. |
Description: | Funding Information: Funding:Thefullandcorrectlistoffundersis: EuropeanUnionHorizon2020programme;grant agreements668303and848196NationalInstitute forHealthResearch. Publisher Copyright: © 2022 Dewez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0275336 |
ISSN: | 1932-6203 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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File | Size | Format | |
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Availability_and_use_of_rapid_.pdf | 2.3 MB | Adobe PDF | View/Open |
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