Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe : A cross-sectional survey of paediatricians

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dc.contributor.authorDewez, Juan Emmanuel
dc.contributor.authorPembrey, Lucy
dc.contributor.authorNijman, Ruud G.
dc.contributor.authordel Torso, Stefano
dc.contributor.authorGrossman, Zachi
dc.contributor.authorHadjipanayis, Adamos
dc.contributor.authorVan Esso, Diego
dc.contributor.authorLim, Emma
dc.contributor.authorEmonts, Marieke
dc.contributor.authorBurns, James
dc.contributor.authorGras-LeGuen, Christèle
dc.contributor.authorKohlfuerst, Daniela
dc.contributor.authorDornbusch, Hans Jürgen
dc.contributor.authorBrengel-Pesce, Karen
dc.contributor.authorMallet, Francois
dc.contributor.authorvon Both, Ulrich
dc.contributor.authorTsolia, Maria
dc.contributor.authorEleftheriou, Irini
dc.contributor.authorZavadska, Dace
dc.contributor.authorde Groot, Ronald
dc.contributor.authorvan der Flier, Michiel
dc.contributor.authorMoll, Henriëtte
dc.contributor.authorHagedoorn, Nienke
dc.contributor.authorBorensztajn, Dorine
dc.contributor.authorOostenbrink, Rianne
dc.contributor.authorKuijpers, Taco
dc.contributor.authorPokorn, Marko
dc.contributor.authorVincek, Katarina
dc.contributor.authorMartinó n-Torres, Federico
dc.contributor.authorRivero, Irene
dc.contributor.authorAgyeman, Philipp
dc.contributor.authorCarrol, Enitan D.
dc.contributor.authorPaulus, Stéphane
dc.contributor.authorCunnington, Aubrey
dc.contributor.authorHerberg, Jethro
dc.contributor.authorLevin, Michael
dc.contributor.authorMujkić, Aida
dc.contributor.authorGeitmann, Karin
dc.contributor.authorDa Dalt, Liviana
dc.contributor.authorValiulis, Arunas
dc.contributor.authorLapatto, Risto
dc.contributor.authorSyridou, Garyfallia
dc.contributor.authorAltorjai, Péter
dc.contributor.authorTorpiano, Paul
dc.contributor.authorStørdal, Ketil
dc.contributor.authorIlly, Károly
dc.contributor.authorMazur, Artur
dc.contributor.authorSpreitzer, Mateja Vintar
dc.contributor.authorRios, Joana
dc.contributor.authorWyder, Corinne
dc.contributor.authorRomankevych, Ivanna
dc.contributor.authorBasmaci, Romain
dc.contributor.authorIbanez-Mico, Salvador
dc.contributor.authorYeung, Shunmay
dc.date.accessioned2023-01-09T12:10:02Z
dc.date.available2023-01-09T12:10:02Z
dc.date.issued2022-12
dc.descriptionFunding Information: Funding:Thefullandcorrectlistoffundersis: EuropeanUnionHorizon2020programme;grant agreements668303and848196NationalInstitute forHealthResearch. Publisher Copyright: © 2022 Dewez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.abstractBackground Point-of-care-tests (POCTs) have been advocated to optimise care in patients with infections but their actual use varies. This study aimed to estimate the variability in the adoption of current POCTs by paediatricians across Europe, and to explore the determinants of variability. Methods and findings A cross-sectional survey was conducted of hospital and primary care paediatricians, recruited through professional networks. Questions focused on the availability and use of currently available POCTs. Data were analysed descriptively and using Median Odds Ratio (MOR) to measure variation between countries. Multilevel regression modelling using changes in the area under the receiver operating characteristic curve of models were used to assess the contribution of individual or workplace versus country level factors, to the observed variation. The commonest POCT was urine dipsticks (UD) which were available to >80% of primary care and hospital paediatricians in 68% (13/19) and 79% (23/29) countries, respectively. Availability of all POCTs varied between countries. In primary care, the country (MOR) varied from 1.61 (95%CI: 1.04-2.58) for lactate to 7.28 (95%CI: 3.04-24.35) for UD. In hospitals, the country MOR varied from 1.37 (95%CI:1.04-1.80) for lactate to 11.93 (95% CI:3.35-72.23) for UD. Most paediatricians in primary care (69%, 795/1154) and hospital (81%, 962/1188) would use a diagnostic test in the case scenario of an infant with undifferentiated fever. Multilevel regression modelling showed that the country of work was more important in predicting both the availability and use of POCTs than individual or workplace characteristics. Conclusion There is substantial variability in the adoption of POCTs for the management of acute infections in children across Europe. To inform future implementation of both existing and innovative tests, further research is needed to understand what drives the variation between countries, the needs of frontline clinicians, and the role of diagnostic tests in the management of acute childhood infections.en
dc.description.statusPeer reviewed
dc.format.extent2355138
dc.identifier.citationDewez, J E, Pembrey, L, Nijman, R G, del Torso, S, Grossman, Z, Hadjipanayis, A, Van Esso, D, Lim, E, Emonts, M, Burns, J, Gras-LeGuen, C, Kohlfuerst, D, Dornbusch, H J, Brengel-Pesce, K, Mallet, F, von Both, U, Tsolia, M, Eleftheriou, I, Zavadska, D, de Groot, R, van der Flier, M, Moll, H, Hagedoorn, N, Borensztajn, D, Oostenbrink, R, Kuijpers, T, Pokorn, M, Vincek, K, Martinó n-Torres, F, Rivero, I, Agyeman, P, Carrol, E D, Paulus, S, Cunnington, A, Herberg, J, Levin, M, Mujkić, A, Geitmann, K, Da Dalt, L, Valiulis, A, Lapatto, R, Syridou, G, Altorjai, P, Torpiano, P, Størdal, K, Illy, K, Mazur, A, Spreitzer, M V, Rios, J, Wyder, C, Romankevych, I, Basmaci, R, Ibanez-Mico, S & Yeung, S 2022, 'Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe : A cross-sectional survey of paediatricians', PloS one, vol. 17, no. 12 , e0275336. https://doi.org/10.1371/journal.pone.0275336
dc.identifier.doi10.1371/journal.pone.0275336
dc.identifier.issn1932-6203
dc.identifier.otherMendeley: 795118e3-7e9b-339c-9513-53526458a4c3
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/10037
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85144588983&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPloS one
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleAvailability and use of rapid diagnostic tests for the management of acute childhood infections in Europe : A cross-sectional survey of paediatriciansen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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