B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
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Date
2022-12
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Abstract
Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens.
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Keywords
3.1 Basic medicine, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, SDG 3 - Good Health and Well-being
Citation
Oleinika, K, Slisere, B, Catalán, D & Rosser, E C 2022, 'B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity', Clinical and Experimental Immunology, vol. 210, no. 3, pp. 263-272. https://doi.org/10.1093/cei/uxac079