Immunogenetic Manifestations of Lyme Borreliosis
No Thumbnail Available
Date
2016-08-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1∗07 (OR 3.52; p = 0.001), HLA-DRB1∗15 (OR 3.02; p = 0.001) and HLA-DRB1 ∗17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles-DRB1∗11(OR 0.37; p = 0.005) and-DRB1∗13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group.
Description
Publisher Copyright: © 2016 by Lilija Kovačuka. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.
Keywords
HLA alleles, Lyme borreliosis, PCR-SSP, 1.6 Biological sciences, 3.3 Health sciences, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General, SDG 3 - Good Health and Well-being
Citation
Kovačuka, L, Eglīte, J, Zālīte, M, Lucenko, I, Vīksna, L & Krūmiņa, A 2016, 'Immunogenetic Manifestations of Lyme Borreliosis', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 70, no. 4, pp. 215-219. https://doi.org/10.1515/prolas-2016-0034