Immunogenetic Manifestations of Lyme Borreliosis

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dc.contributor.authorKovačuka, Lilija
dc.contributor.authorEglīte, Jeļena
dc.contributor.authorZālīte, Māra
dc.contributor.authorLucenko, Irina
dc.contributor.authorVīksna, Ludmila
dc.contributor.authorKrūmiņa, Angelika
dc.contributor.institutionKlīniskās imunoloģijas un imunoģenētikas starpkatedru laboratorija
dc.contributor.institutionDepartment of Infectology
dc.date.accessioned2021-04-20T13:55:01Z
dc.date.available2021-04-20T13:55:01Z
dc.date.issued2016-08-01
dc.descriptionPublisher Copyright: © 2016 by Lilija Kovačuka. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.
dc.description.abstractIn this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1∗07 (OR 3.52; p = 0.001), HLA-DRB1∗15 (OR 3.02; p = 0.001) and HLA-DRB1 ∗17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles-DRB1∗11(OR 0.37; p = 0.005) and-DRB1∗13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.format.extent78543
dc.identifier.citationKovačuka, L, Eglīte, J, Zālīte, M, Lucenko, I, Vīksna, L & Krūmiņa, A 2016, 'Immunogenetic Manifestations of Lyme Borreliosis', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 70, no. 4, pp. 215-219. https://doi.org/10.1515/prolas-2016-0034
dc.identifier.doi10.1515/prolas-2016-0034
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3874
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84983417758&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHLA alleles
dc.subjectLyme borreliosis
dc.subjectPCR-SSP
dc.subject1.6 Biological sciences
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.subjectSDG 3 - Good Health and Well-being
dc.titleImmunogenetic Manifestations of Lyme Borreliosisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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