Cell proliferation and apoptosis in wistar rat kidney after renal mass ablation and low-dose irradiation
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Date
2010
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Abstract
Cell proliferation and apoptosis in the remnant rat kidney after treatment with lowdose irradiation was investigated. Material and methods. In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9). Results. Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation. Conclusion. The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.
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Keywords
Apoptosis, Cell proliferation, Low-dose radiation, Rat, Remnant kidney, 3.1 Basic medicine, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General Medicine
Citation
Aunapuu, M, Arend, A, Ots, M & Pilmane, M 2010, 'Cell proliferation and apoptosis in wistar rat kidney after renal mass ablation and low-dose irradiation', Medicina, vol. 46, no. 3, pp. 204-210. https://doi.org/10.3390/medicina46030029