Significance of hypouricaemia in the development of neurodegenerative diseases
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Date
2021-04-01
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Abstract
Hypouricaemia has received relatively little attention in the literature. As a result, there is lessawareness or understanding of the potential risks of low uric acid levels. Emerging research indi-cates that normal uric acid levels may have an antioxidative and neuroprotective effect. Thisstudy aims to investigate possible associations between hypouricaemia and neurodegenerativedisease. Data was collected from seventy-seven outpatients and inpatients who underwent rou-tine uric acid testing, who were then stratified into patients with and without neurodegenerativedisease. Patients with renal pathologies and patients using uric acid altering medications were ex-cluded from the study. There was a significant difference in the prevalence of Alzheimer’s diseasebetween hypouricemic and normouricemic patients (p= 0.001), however there was no differencein the prevalence of vascular dementia (p= 0.45). This study provides evidence that hypouricae-mia has potential effects on health, specifically on the rate of neurodegenerative diseases suchas Alzheimer’s disease and gives weight to the potential neuroprotective role of uric acid.
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Publisher Copyright: © 2021 Sciendo. All rights reserved.
Keywords
uric acid, Alzheimer’s disease, vascular dementia, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database
Citation
Trapp, M, Mihailova, A, Kakurina, N & Murovska, M 2021, 'Significance of hypouricaemia in the development of neurodegenerative diseases', Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences, vol. 75, no. 2, pp. 92-98. https://doi.org/10.2478/prolas-2021-0015