Significance of hypouricaemia in the development of neurodegenerative diseases

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dc.contributor.authorTrapp, Maximiliane
dc.contributor.authorMihailova, Anna
dc.contributor.authorKakurina, Natalija
dc.contributor.authorMurovska, Modra
dc.contributor.institutionFaculty of Medicine
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2021-10-21T10:25:01Z
dc.date.available2021-10-21T10:25:01Z
dc.date.issued2021-04-01
dc.descriptionPublisher Copyright: © 2021 Sciendo. All rights reserved.
dc.description.abstractHypouricaemia has received relatively little attention in the literature. As a result, there is lessawareness or understanding of the potential risks of low uric acid levels. Emerging research indi-cates that normal uric acid levels may have an antioxidative and neuroprotective effect. Thisstudy aims to investigate possible associations between hypouricaemia and neurodegenerativedisease. Data was collected from seventy-seven outpatients and inpatients who underwent rou-tine uric acid testing, who were then stratified into patients with and without neurodegenerativedisease. Patients with renal pathologies and patients using uric acid altering medications were ex-cluded from the study. There was a significant difference in the prevalence of Alzheimer’s diseasebetween hypouricemic and normouricemic patients (p= 0.001), however there was no differencein the prevalence of vascular dementia (p= 0.45). This study provides evidence that hypouricae-mia has potential effects on health, specifically on the rate of neurodegenerative diseases suchas Alzheimer’s disease and gives weight to the potential neuroprotective role of uric acid.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent190370
dc.identifier.citationTrapp, M, Mihailova, A, Kakurina, N & Murovska, M 2021, 'Significance of hypouricaemia in the development of neurodegenerative diseases', Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences, vol. 75, no. 2, pp. 92-98. https://doi.org/10.2478/prolas-2021-0015
dc.identifier.doi10.2478/prolas-2021-0015
dc.identifier.issn2255-890X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6696
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85106290705&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecturic acid, Alzheimer’s disease, vascular dementia
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleSignificance of hypouricaemia in the development of neurodegenerative diseasesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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