Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry
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Date
2019-12
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Abstract
MK-801, a N-methyl-D-aspartate receptor antagonist, is widely used in animal preclinical experiments to induce memory and learning impairments and schizophrenia-like behavior. In the present study, we compared the plasma and brain tissue concentrations of MK-801 after intraperitoneal (i.p.) or subcutaneous (s.c.) administration at a dose of 0.1 mg/kg in male ICR mice. Moreover, these data present the optimization of ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the analysis of MK-801 in biological samples. Procedures for the preparation of brain tissue and plasma samples and instrumental analysis are described. This article is related to a research article entitled “Effects of the N-methyl-D-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration” [1].
Description
Funding Information: This research was supported by the European Regional Development Fund (ERDF) project No. 1.1.1.2/VIAA/1/16/244 “The role of sigma-1 receptor in sexual behavior”. Publisher Copyright: © 2019 The Author(s)
Keywords
Bioavailability, i.p. and s.c. administration route, Mice, MK-801, UPLC-MS/MS, 3.1 Basic medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General
Citation
Svalbe, B, Grinberga, S, Stelfa, G, Vavers, E, Zvejniece, B, Sevostjanovs, E, Dambrova, M & Zvejniece, L 2019, 'Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry', Data in Brief, vol. 27, 104623. https://doi.org/10.1016/j.dib.2019.104623