Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip
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2017-09-01
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Abstract
Background: Orofacial clefts are one of the most common birth defects with multifactorial and only partly understood morphopathogenesis. Objective: The aim of this study was to evaluate the presence of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip. Methods: Lip mucosa tissue samples were obtained during surgical cleft correction from seven 2 to 6 months old children. Prepared tissue sections were stained by immunohistochemistry for TGF-β1, HGF, IGF-1 and IGF-1R. The intensity of staining was graded semiquantitatively. Results: We found numerous TGF-β1 and HGF-containing epithelial and connective tissue cells, moderate number of IGF-1 immunoreactive cells and even less pronounced presence of IGF-1R-positive cells. Conclusion: TGF-β1 and HGF are present in defective epithelia and soft tissue in cleft affected lip. Expressions of IGF-1 and IGF-1R show significant differences, and both factors play a role in the morphopathogenesis of clefts.
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Publisher Copyright: © 2017 Sidhom and Pilmane.
Keywords
Cleft, HGF, IGF-1, IGF-1R, Lip mucosa, Orofacial defects, TGF-β1, 3.1 Basic medicine, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Dermatology
Citation
Sidhom, E & Pilmane, M 2017, 'Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip', Open Dermatology Journal, vol. 11, pp. 46-52. https://doi.org/10.2174/1874372201711010046