Please use this identifier to cite or link to this item:
10.22038/IJORL.2021.53716.2842
Title: | Remodeling Factors, Transcription Factors and Angiogenetic Factors in Cholesteatoma in Ontogenetic Aspect |
Authors: | Dambergs, Kristaps Sumeraga, Gunta Pilmane, Māra Department of Otorhinolaryngology Institute of Anatomy and Anthropology |
Keywords: | Cholesteatoma;Transcription factor;Metalloproteases;Vascular endothelial growth factor;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Otorhinolaryngology |
Issue Date: | Mar-2022 |
Citation: | Dambergs , K , Sumeraga , G & Pilmane , M 2022 , ' Remodeling Factors, Transcription Factors and Angiogenetic Factors in Cholesteatoma in Ontogenetic Aspect ' , Iranian Journal of Otorhinolaryngology , vol. 34 , no. 2 , pp. 71-81 . https://doi.org/10.22038/IJORL.2021.53716.2842 |
Abstract: | Introduction: The main goal of our study was to describe the transcription factor (NF-κβ), angiogenetic factor (VEGF), and remodeling markers (MMP-9 and TIMP-4) of the cholesteatoma tissue compared to control skin tissue. There are still uncertainties how transcription, angiogenetic and remodeling factors affect the cholesteatoma course. Materials and Methods: Eight cholesteatoma tissue specimens were retrieved from children, seven – from adults, seven skin controls – from cadavers. Obtained material immunohistochemically were stained for NF-κβ, MMP-9, TIMP-4, VEGF. Non-parametric statistic methods were used. Results: A statistically significant higher numbers of NF-κβ and TIMP-4 immunoreactive cells in the cholesteatoma compared to control group. A very strong positive correlation between MMP-9 and TIMP-4 was seen in the patient group. A strong positive correlation - between MMP-9 in matrix and MMP-9, VEGF in perimatrix, between TIMP-4 in matrix and TIMP-4 in perimatrix, NF-κβ in the matrix and VEGF; between TIMP-4 in perimatrix and NF-κβ in the matrix. Conclusions: Correlation between MMP-9 and TIMP-4 suggests that TIMP-4 in cholesteatoma tissue intercorrelates to MMP9. TIMP-4 likely regulates the development of cholesteatoma. Disbalance between MMPs and TIMPs affects NFκβ and causes uncontrolled cell proliferation and immune response in this tumor. There is a lack of VEGF strong expression in cholesteatoma perimatrix. |
Description: | Publisher Copyright: © 2022 Mashhad University of Medical Sciences. All rights reserved. |
DOI: | 10.22038/IJORL.2021.53716.2842 |
ISSN: | 2251-7251 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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IJORL_Volume_34_Issue_2_Pages_71_81.pdf | 2.27 MB | Adobe PDF | View/Open |
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