Autosomïli dominantas nieru policistozes klïniskās manifestācijas

Abstract

Autosomāli dominanta nieru policistoze (ADNP) ir multisistēmiska un progresējoša iedzimta nieru slimība. ADNP klīniskās izpausmes ir ļoti dažādas, variē vecuma ziņā, ieskaitot nieru un ārpusnieru pazīmes. Pētījuma mērķis ir analizēt biežākās ADNP ārpusnieru izpausmes un salīdzināt ārpusnieru pazīmes starp divām vecuma grupām: jaunākiem par 65 gadiem un personām vecumā no 65 gadiem (vecāka gadagājuma cilvēku grupa).

Materials and methods: A retrospective study was made including 90 patients with AD PKD from Pauls Stradins Clinical University Hospital outpatient clinic. Data were collected from ambulatory cards and were analyzed by IBM SPSS Statistics version 26.0 (p<0.05). The study was approved by the Institutional Ethics Review Board. Results: 90 patients with the mean age of 62±10.2SD years, 65 (72.2%) were females and 25 (27.8%) were males. The patients’ mean age of the AD PKD diagnosis was 35±9,36 years in men and 33±9,82 years in women. Most common extra-renal manifestations were liver cysts (91,1%), hernias (15,6%) and diverticulosis (13,3%). The most common extra-renal manifestations in elderly patients were liver cysts, which were presented in 97.4%( vs 86.3% in patients younger than age 65 years). Statistically significant differences between study age-groups were found in the frequency of diverticulosis, hernias and common bile duct dilatation(chi square test, p<0.05). Conclusion(s): The most common extra-renal manifestation of autosomal dominant polycystic kidney disease in both age - groups is liver cysts, but not statistically significant difference was found between study groups.

Introduction: Autosomal dominant polycystic kidney disease (AD PKD) is a multisystemic and progressive hereditary disorder. AD PKD clinical manifestations are highly varied and age-related, including renal and extra-renal features. The aim of the study is to analyze the most common extra-renal manifestations of the disease and compare extra-renal features between the two age-groups: younger than 65 years old and subjects aged 65 and older (elderly group). Materials and methods: A retrospective study was made including 90 patients with AD PKD from Pauls Stradins Clinical University Hospital outpatient clinic. Data were collected from ambulatory cards and were analyzed by IBM SPSS Statistics version 26.0 (p<0.05). The study was approved by the Institutional Ethics Review Board. Results: 90 patients with the mean age of 62±10.2SD years, 65 (72.2%) were females and 25 (27.8%) were males. The patients’ mean age of the AD PKD diagnosis was 35±9,36 years in men and 33±9,82 years in women. Most common extra-renal manifestations were liver cysts (91,1%), hernias (15,6%) and diverticulosis (13,3%). The most common extra-renal manifestations in elderly patients were liver cysts, which were presented in 97.4%( vs 86.3% in patients younger than age 65 years). Statistically significant differences between study age-groups were found in the frequency of diverticulosis, hernias and common bile duct dilatation(chi square test, p<0.05). Conclusion(s): The most common extra-renal manifestation of autosomal dominant polycystic kidney disease in both age - groups is liver cysts, but not statistically significant difference was found between study groups.