Please use this identifier to cite or link to this item:
10.3390/medicina56100497
Title: | Structural analysis of brain hub region volume and cortical thickness in patients with mild cognitive impairment and dementia |
Authors: | Zdanovskis, Nauris Platkājis, Ardis Kostiks, Andrejs Karelis, Guntis Department of Radiology |
Keywords: | Brain hubs;Brain networks;Cortical thickness;Dementia;Mild cognitive impairment;Neuroimaging;White matter volume;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine |
Issue Date: | 1-Oct-2020 |
Citation: | Zdanovskis , N , Platkājis , A , Kostiks , A & Karelis , G 2020 , ' Structural analysis of brain hub region volume and cortical thickness in patients with mild cognitive impairment and dementia ' , Medicina (Lithuania) , vol. 56 , no. 10 , 497 , pp. 1-8 . https://doi.org/10.3390/medicina56100497 |
Abstract: | Background and Objectives: A complex network of axonal pathways interlinks the human brain cortex. Brain networks are not distributed evenly, and brain regions making more connections with other parts are defined as brain hubs. Our objective was to analyze brain hub region volume and cortical thickness and determine the association with cognitive assessment scores in patients with mild cognitive impairment (MCI) and dementia. Materials and Methods: In this cross-sectional study, we included 11 patients (5 mild cognitive impairment; 6 dementia). All patients underwent neurological examination, and Montreal Cognitive Assessment (MoCA) test scores were recorded. Scans with a 3T MRI scanner were done, and cortical thickness and volumetric data were acquired using Freesurfer 7.1.0 software. Results: By analyzing differences between the MCI and dementia groups, MCI patients had higher hippocampal volumes (p <0.05) and left entorhinal cortex thickness (p <0.05). There was a significant positive correlation between MoCA test scores and left hippocampus volume (r = 0.767, p <0.01), right hippocampus volume (r = 0.785, p <0.01), right precuneus cortical thickness (r = 0.648, p <0.05), left entorhinal cortex thickness (r = 0.767, p <0.01), and right entorhinal cortex thickness (r = 0.612, p <0.05). Conclusions: In our study, hippocampal volume and entorhinal cortex showed significant differences in the MCI and dementia patient groups. Additionally, we found a statistically significant positive correlation between MoCA scores, hippocampal volume, entorhinal cortex thickness, and right precuneus. Although other brain hub regions did not show statistically significant differences, there should be additional research to evaluate the brain hub region association with MCI and dementia. |
Description: | Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved. |
DOI: | 10.3390/medicina56100497 |
ISSN: | 1010-660X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Structural_Analysis_of_Brain_Hub_Region_Volume.pdf | 280.05 kB | Adobe PDF | View/Open |
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